Jobs and Careers

Senior Systems Engineer

South San Francisco, United Statesfull_timeVerifiedPosted 21 Jul 2026

About the role

Position Summary

We are seeking an innovative and highly motivated Senior Systems Engineer who will make significant contributions to the development of our advanced cell therapy manufacturing platform.

The ideal candidate will have demonstrated experience in biomedical-related instruments and consumables development, integration, and verification activities. As a Senior Systems Engineer, you are expected to readily learn and adapt to Cell Shuttle technologies, take ownership of various tasks, and successfully drive them to completion. In your daily work, you will provide in-depth analysis for system characterization and troubleshooting, and help guide important decisions for continuous improvement projects.

The primary focus of this role is to be responsible for maintaining and refining system requirements and architecture. Create and maintain documents, models & diagrams describing functional and physical decompositions, interface definitions, and flow diagrams. Support architecture definition by working with subsystem design teams to align overlapping design requirements /constraints and drive teams in developing concepts, evaluating risks, and efficiently converging on a design path. Provide support to sub-system engineers in the development of models that guide lower-level design decisions. Assist teams with complex root-cause analysis in which there are many possible root causes that involve various areas of physics, using a structured approach for problem-solving. Work closely with other members of the team to formulate, execute, and analyze verification and validation activities.

Candidates should enjoy working in a fast-paced, mission-driven environment and be prepared to tackle a broad selection of challenges as the company scales up from R&D systems to full-scale operations.

Requirements

Masters degree in Engineering, Physics or Biotech Automation, and at least one year of experience as Systems Engineer, Applications Engineer, R&D Engineer or Integration Engineer in a biotechnology field, including a year of experience with MATLAB or Python and working knowledge of at least one data visualization or statistical tool (e.g. JMP, Minitab or Tableau)

This is Cellares

Cellares is the first Integrated Development and Manufacturing Organization (IDMO) and takes an Industry 4.0 approach to mass manufacturing the living drugs of the 21st century. The company is both developing and operating integrated technologies for cell therapy manufacturing to accelerate access to life-saving cell therapies. The company’s Cell Shuttle integrates all the technologies required for the entire manufacturing process in a flexible and high-throughput platform that delivers true walk-away, end-to-end automation. Cell Shuttles will be deployed in Cellares’ Smart Factories around the world to meet total patient demand for cell therapies at global scale. Partnering with Cellares enables academics, biotechs, and pharma companies to accelerate drug development and scale out manufacturing, lower process failure rates, lower manufacturing costs, and meet global patient demand.

The company is headquartered in South San Francisco, California with its commercial-scale IDMO Smart Factory in Bridgewater, New Jersey. The company is backed by world-class investors and has raised over $355 million in financing.

Leveling will be based on overall experience, education, and demonstration of knowledge throughout the interview process.