Sr. Scientist/Principal Scientist, Toxicology (Small Molecule)

<p><strong>Salary Band: $160,000-$220,000</strong></p> <p><strong>Location: Downtown Boston, MA (In-Office Minimum 3 Days/week)</strong></p> <p><strong>Position Summary</strong></p> <p>Antares Therapeutics is seeking an enthusiastic and self‑motivated <strong>Senior Scientist/Principal Scientist, Toxicology</strong> to join the <strong>Nonclinical Development</strong> group and support nonclinical safety assessment activities from discovery through <strong>IND‑enabling stages</strong> across the Antares pipeline.</p> <p>The successful candidate will play a key role in the <strong>design, execution, and interpretation of nonclinical safety studies</strong>, working both <strong>hands‑on in the laboratory</strong> and in close collaboration with <strong>external CROs</strong>. This role requires scientific independence, strong technical expertise in <strong>in vitro and in vivo safety assessment</strong>, and effective cross‑functional collaboration in a fast‑paced, matrixed environment.</p> <p><strong>Key Responsibilities</strong></p> <ul> <li>Serve as a nonclinical safety representative on <strong>cross‑functional Discovery and Development project teams</strong>, supporting program progression through IND‑enabling stages.</li> <li><strong>Design, execute, and troubleshoot</strong> nonclinical safety studies, including hands‑on assay execution, data generation, and interpretation. Up to 40% of time in the lab.&nbsp;</li> <li>Support the <strong>oversight of GLP and non‑GLP nonclinical safety studies</strong> conducted at CROs, including active involvement in troubleshooting assay‑ and study‑related challenges.</li> <li>Work in the laboratory to establish and run <strong>in vitro safety assays</strong>, with an emphasis on <strong>New Approach Methodologies (NAMs)</strong>.</li> <li>Analyze and interpret study data, contributing to <strong>study reports, regulatory documentation, and IND‑supporting materials</strong> under guidance.</li> <li>Collaborate closely with <strong>Pharmacology, DMPK, and other functional teams</strong> to support exploratory and mechanistic safety studies.</li> <li>Identify and communicate potential safety findings and actively contribute to discussions on <strong>risk assessment, data interpretation, and next‑step recommendations</strong>.</li> <li>Ensure all studies and internal activities are conducted in compliance with <strong>regulatory guidelines, GLP principles, and internal standards</strong>.</li> </ul> <p><strong>Required Qualifications</strong></p> <ul> <li>P