Director, Clinical Translational Safety Lead

At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at https://www.jnj.com

Job Function:

Discovery & Pre-Clinical/Clinical Development

Job Sub Function:

Clinical Development & Research – MD

Job Category:

People Leader

All Job Posting Locations:

Horsham, Pennsylvania, United States of America, Raritan, New Jersey, United States of America, Spring House, Pennsylvania, United States of America, Titusville, New Jersey, United States of America

Job Description:

Johnson & Johnson is recruiting for a Director, Clinical Translational Safety Lead to be located in Spring House, PA; Horsham, PA; Raritan, NJ; or Titusville, NJ.

Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow. Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way. Learn more at https://www.jnj.com/innovative-medicine

Job Summary:

As a Clinical Translational Safety Lead within the Preclinical Sciences and Translational Safety team (PSTS), you will play an important role in guiding the strategy for mechanistic de-risking and understanding of safety signals that arise in pre-clinical and clinical development within a robust and multi-modality portfolio covering multiple therapeutic areas (oncology, immunology, neurosciences, ophthalmology, others). You will be part of the Translational Safety leadership team, working in a global organization of motivated and passionate scientists with expertise in toxicology, safety pharmacology, pathobiology, DMPK and bioanalysis. The individual contributor role (reporting to the Executive Director, Global Translational Safety) requires a well-rounded physician scientist with an investigative mind and a track record of excellent communication and collaboration in cross-functional, complex, and fast-paced, highly matrixed environments. This role requires a deep understanding of systems and pathway biology, mechanistic pathobiology and biochemistry, and the ability to “translate” pathologic and clinical findings into disease phenotypes. 

The Clinical Translational Safety Lead will build strong partnerships with Translational Research, Global Medical Safety and Clinical Pharmacology and will work in collaboration with key stakeholders in investigative toxicology, pathobiology, safety pharmacology and other pre-clinical sciences to set investigative pre-clinical strategy and bridge knowledge between pre-clinical and clinical disciplines to advance new medicines into the clinic. You will contribute to our discovery programs by providing expert interpretation and contextualization of competitive intelligence around clinical safety data in collaboration with medical safety officers, translational leads and compound development team leaders. This role is responsible for establishing a robust translational safety assessment framework, ensuring that clinical insights are translated back into discovery to inform and optimize our preclinical safety models and ultimately improve the safety profiles of future therapies.

What’s in it for you:

If you have a creative scientific, translational and strategic mindset and you thrive on (1) identifying opportunities for (cross disciplinary) project impact, (2) raising the scientific bar of our discipline and (3) challenging/defending scientific and/or strategic project views to senior management and senior governance bodies, this will be an excellent opportunity to (1) further grow you career, (2) significantly impact drug discovery and development and (3) ultimately to help patients.

In addition, our R&D culture of being courageous in science and unwavering in execution and of being one team that CARES for each other enables us to navigate uncertainty, seize opportunities, and lead where medicine is going.

Key Responsibilities:

• Develop and maintain strong collaborative partner