Associate Director, Clinical Scientist – Neuroimmunology

Are you a scientist with a passion for clinical drug development and a strong scientific foundation, who wants to learn the craft of clinical science on breakthrough cell and immunotherapies for immune-mediated neurological disease? Do you have sharp analytical instincts, a search-and-find mindset in complex clinical data, and the collaborative temperament to thrive in a cross-functional team? If so, we invite you to join us. We are seeking a Clinical Scientist, Neuroimmunology to support our neuroimmunology portfolio, starting in multiple sclerosis and extending to additional immune-mediated indications and modalities. 

AstraZeneca is a global, science-led, patient-focused biopharmaceutical company that discovers, develops and commercializes prescription medicines for some of the world's most serious diseases. Within Immunology R&D, our Neuroimmunology team is building a world-class capability to accelerate the delivery of transformative cell therapies and immunotherapies for patients with immune-mediated neurological disease. AZ is a place built on courage, curiosity and collaboration, and we make bold decisions driven by patient outcomes. 

The Associate Director, Clinical Scientist is a member of a multi-disciplinary study team, working in close partnership with the Study Physician and fellow clinical scientists. You will provide clinical-scientific support to help monitor, track, and analyze participant data across the study lifecycle, and contribute to the documents and day-to-day clinical-science work that keep studies inspection-ready and decision-enabling. You will collaborate with all groups involved in clinical development, including Clinical Operations, Data Management, Biostatistics, Clinical Pharmacology (DMPK), Pharmacovigilance, Translational Medicine, and Regulatory. This is an excellent opportunity to build clinical-development craft on advanced modalities within a supportive, mentoring team. You will report to the Global Clinical Head, Neuroimmunology, or their designee, and work closely with the Study Physician, fellow clinical scientists, and the Global Clinical Program Lead (GCPL), who leads the program's clinical development strategy. Medical-judgement questions are escalated to the Study Physician, and program-strategy items to the GCPL. 

Typical Accountabilities -

Clinical data review and monitoring

• Support ongoing review, tracking, and analysis of clinical-trial participant data, reviewing patient profiles, data listings, summary tables, laboratory and other safety parameters, and coded terms for consistency and completeness. 

• Contribute to the interpretation of emerging clinical data and identification of clinically meaningful findings, trends, and questions for further evaluation by the study team. 

• Assist with routine safety and efficacy data review, help flag events of interest or data trends needing further investigation, and prepare preliminary summaries for the study team. 

• Contribute to query generation, coding reconciliation (AE/SAE, medical/surgical history, concomitant medications), and edit-check refinement in collaboration with Data Management and Biostatistics, and support database-lock readiness activities and cross-checks. 

Documents and operational translation

• Contribute to authoring and review of clinical documents in alignment with the clinical development plan, such as protocols and amendments, protocol clarification letters, IBs, ICFs, CRFs and eCRF completion guidelines, medical monitoring plans, charters, lab and pharmacy manuals, and training materials. 

• Help translate protocol intent into operational deliverables, and support maintenance of the protocol clarification log. 

• Contribute to preparation and review of safety narratives, regulatory-submission sections, responses to health-authority requests, and materials for safety review committees (SRC, IDMC, DMC), including data review and presentation preparation. 

Endpoint integrity (MS-specific)

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