Business Engagement & Technology Senior Principal Analyst - Manufacturing Systems

Job Description

General Summary:

Vertex is a global biotechnology company that invests in scientific innovation. The Digital, Technology and Engineering (DTE) Research, Pre-Clinical, Manufacturing and Supply (RPMS) group’s mission is to improve the lives of patients through digital, data, and technology innovation.

Vertex is in a transformational period where we are accelerating our capabilities, technology and data to augment our scientific mission and enable Vertex to grow in scale; ensuring we remain on the forefront of science, medicine and technology. 

We are seeking a dynamic and experienced Senior Principal Analyst – Manufacturing Systems to join our team and drive our digital transformation initiatives.

The Senior Principal Analyst – Manufacturing Systems is a key role within the CMC (Chemistry, Manufacturing, and Controls) function of the DTE RPMS group. This role will oversee the development, implementation, and optimization of data and technology solutions to support global internal and external manufacturing operations with real-time data flow, ensuring alignment with Vertex's strategic goals and compliance with industry standards. This position requires a tactical leader who can manage a complex data and technology environment spanning multiple internal and external partners and drive continuous improvement in manufacturing processes through innovative technological solutions.

Key Duties and Responsibilities:

Vision and Strategy

• Enable the data and technology strategy for manufacturing, ensuring alignment with business objectives to deliver a digital transformation in the pace and velocity of real-time insight creation.
• Implement data and technology solutions to be deployed within Vertex and between its external manufacturing partners, ensuring they meet Vertex's quality, security, regulatory and compliance standards.
• Support digital transformation initiatives to enhance data-driven decision-making across the organization, ensuring Vertex remains at the forefront of technological advancements.
• Collaborate with cross-functional teams to ensure the internal and external manufacturing data and technology strategy supports broader organizational objectives and regulatory requirements.

Operational Execution

• Implementation and management of data and technology solutions across the Vertex internal and external manufacturing network, including integration of Manufacturing Execution Systems/Electronic Batch Records, Process Analytical Technology, SCADA, manufacturing equipment/instrumentation, LIMS, QMS, CMMS, Finite Scheduling and Data Historian Systems to enable manufacturing operations, ensuring products are manufactured on time, within budget, and to the required quality standards.
• Lead installation, configuration and troubleshooting processes for integrated manufacturing applications. Support manufacturing equipment and instrument connectivity.
• Specify and coordinate the implementation of cloud and on-premise high availability computing environments (servers, databases, network, port/firewall configuration, user group and application-level cybersecurity). Manage SSL and server certificate processes. Oversee disaster recovery failover procedures, test planning, and execution.
• Guide integration of manufacturing system data flows through mapping exercises and technical task execution. Conduct data quality assessments for integration project databases.
• Develop SQL code for custom requirements, performance analysis, debugging, and reusable application queries.
• Establish connectivity to enable data cataloging, reporting and integration (Collibra, Tibco/PowerBI and Informatica iPaaS).  Support data management and governance initiatives working collaboratively on data cataloging and normalization efforts.
• Interact with offshore support, application development, and system support teams to ensure a secure, and properly configured application environment meeting the 7x24 availability needs of manufacturing.
• Support digital transformation initiatives such as predictive scheduling and control, digital AI/ML-driven process optimization and automation, and predictive analytics for improved manufacturing and quality control.
• Ensure data and technology solutions are developed on time, within budget, and to the required quality standards.
• Support adoption of cloud-based solutions, IoT-enabled manufacturing, and automation technologies improve efficiency, scalability, and cost-effectiveness.
• Ensure compliance with regulatory requirements by implementing secure, validated digital systems.
• Evaluate and implement emerging technologies to enhance Vertex decision-making prior to, during and after manufacturing.

Leadership

• Overs