Executive Director, Head of Portfolio Management

Revolution Medicines is a clinical-stage precision oncology company focused on developing novel targeted therapies to inhibit frontier targets in RAS-addicted cancers.  The company’s R&D pipeline comprises RAS(ON) Inhibitors designed to suppress diverse oncogenic variants of RAS proteins, and RAS Companion Inhibitors for use in combination treatment strategies. As a new member of the Revolution Medicines team, you will join other outstanding professionals in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway.

The Opportunity:

We are looking for a highly motivated individual with experience in portfolio management and decision analysis and a passion for developing solutions for complex problems to build out this cross-functional capability and help shape our portfolio strategy. This is an exciting opportunity to build out and lead the Portfolio Management function at Revolution Medicines. This position will report to the VP, Program, Portfolio and Alliance Management (PPAM) and will be based at our headquarters in Redwood City, CA.

As the Head of Portfolio Management, you will be responsible for the Portfolio Management function, facilitating the Portfolio Working Group (PWG), and evolving the wider portfolio management capability within Revolution Medicines. This is a highly cross-functional role, working closely with the PWG (currently chaired by our President, R&D), Program Teams, Analytics and Insights, Finance, and many other relevant functions. You will be an active member of the PPAM LT, collaborating closely to develop talent, share learnings, cultivate and implement best practices, and ensure consistent ways of working across PPAM and the broader organization.

The Head of Portfolio Management must be entrepreneurial, able to “roll up their sleeves” and thrive in a fast-paced, highly cross-functional environment. You are an exceptional strategic and critical thinker, have a passion for interpreting and analyzing complex data, and have strong interpersonal skills that you will leverage to successfully partner cross-functionally with internal teams and senior stakeholders.  

• Develop and implement a vision for Revolution Medicine’s Portfolio Management function.

• Lead the build out of the portfolio management capability, partnering with R&D Leadership, Commercial, Finance, Program Management and other functions – including

  • Identify current and future needs and evolve capabilities to remain fit for purpose as our portfolio continues to increase in complexity.

  • Implement best practices including development and use of qualitative and quantitative methods for portfolio prioritization, decision analysis, project trade-offs, and assigning probability of success to support decision making.

  • Develop portfolio dashboards and reports supporting executive decision making.

• Facilitate and project manage the Portfolio Working Group (PWG) – including

  • Partner with the PWG Chair to define appropriate strategic context for the portfolio and program decisions and execution.

  • Plan and prioritize agenda topics by business criticality ensuring effective and timely discussion and resolution, in partnership with the PWG Chair and Program Team Leads.

  • Prepare stakeholders and presenters and assist in developing appropriate materials.

• Drive the development and collation of R&D inputs for program and portfolio evaluations, including target product profiles, development plans and probability of success assessment, and ensure consistency with financial and commercial inputs.

• Closely partner with Program Teams and relevant functions on the application of analytical tools and frameworks to clearly present options and solutions to optimize the portfolio and help them navigate through the relevant decision-making bodies.

• Maintain a detailed understanding of the shape and drivers of the portfolio through pro-active involvement with key stakeholders and assess impact of external developments on our portfolio.

• Lead and manage other high impact projects that arise outside of regular portfolio planning cycles, ensuring that these one-off initiatives are aligned to overall business objectives.

• Contribute to the overall strategy and development of PPAM, as a member of the PPAM LT.

• Uphold an open, inclusive and collaborative culture with a focus on shared learning and people development.

Required Skills, Experience and Education:

• 10+ years' experience in the biotech/pharmaceutical industry with 5+ years' experience in portfolio management, portfolio planning or similar function(s).

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