Postdoctoral Associate - Bioengineering

About George R. Brown School of Engineering and Computing

The George R. Brown School of Engineering and Computing ranks among the top 20 undergraduate engineering programs (US News & World Report) and is strongly committed to nurturing the aspirations of faculty, staff, and students in an inclusive environment.

We seek greater representation of women, minorities, people with disabilities, and veterans in disciplines in which they have historically been underrepresented; to attract international students from a wider range of countries and backgrounds; to accelerate progress in building a faculty and staff who are diverse in background and thought, and we support an inclusive environment that fosters interaction and understanding within our diverse community.

Position Summary 

The McHugh Lab in the Department of Bioengineering at Rice University (Houston, TX) seeks to hire a postdoctoral associate working in the area of immunology for novel vaccine development. At a high level, the McHugh Lab is focused on the development of translational drug delivery platforms with the potential to address a variety of conditions ranging from prophylaxis for infectious diseases to cancer therapies. These bespoke delivery systems often leverage a combination of material properties and advanced manufacturing techniques and engage the immune system to fight disease. 

The postdoctoral fellow selected for this position will co-lead an interdisciplinary project funded by the Bill & Melinda Gates Foundation that aims to employ a controlled-release vaccine delivery platform to create combination vaccines with otherwise incompatible vaccines. Specifically, we aim to encapsulate a next-generation polio vaccine inside particles fabricated using the Particles Uniformly Liquified and Sealed to Encapsulate Drug (PULSED) platform to offset the timing of release from a co-delivered soluble vaccine to prevent immunological interference. The responsibilities of the postdoctoral fellow selected for this position will include evaluating vaccine stability and release in vitro as well as planning and performing in vivo experiments to characterize the immune response to multiple antigens. Additionally, this postdoc will be responsible for directing the work of a research technician working on the project and collaborating with a postdoc specializing in the development of new materials to be used with the PULSED platform.

The ideal candidate will be creative, highly motivated, experienced working with animals, and have a deep understanding of immunology and immunological characterization techniques. The candidate should also have strong written and oral communication skills, as evidenced by previous publications and presentations. As a senior member of the lab, the candidate will also be expected to spend a small portion of their time supporting and training junior lab members and will also assist in the preparation of research proposals. In turn, the candidate will receive one-on-one mentorship from the PI, support for their postdoctoral fellowship applications, and (if desired) job applications for faculty positions in academia.

This position is a one-year term-limited position funded by a grant with the expectation of renewal beyond the initial appointment period with satisfactory performance. Funding for this project has been secured through August 2027 and funds to support continued employment beyond that date will likely be available. This position is available immediately; however, the start date is flexible and could be delayed until late Spring 2025 based on the needs of the applicant. 

Due to its location at the boundary between Rice University and the Texas Medical Center—the largest medical center in the world—the lab is uniquely positioned to advance its technologies towards the clinic with active collaborations with clinician-scientists at MD Anderson Cancer Center, the Baylor College of Medicine, Houston Methodist, and Texas Heart Institute. 

Hiring range - Minimum salary $61,008

Requirements

• Ph.D. or other doctoral degree in immunology, biomedical engineering, bioengineering, vaccinology, biology, or related fields
• No experience required

Skills Required

• Knowledge of with ELISA
• Familiarity with humoral and cellular immune characterization
• Familiarity with in vivo protocol development and execution
• Strong written and oral communication skills, including experience preparing and submitting manuscripts
• Ability to work both independently and collaboratively

Preferences

• Experience mentoring early-career trainees
• Previous experience with drug or vac