Summary 

The Department of Biophysics at the Medical College of Wisconsin is seeking a highly motivated Research Scientist to join our research team focused on the structural and functional analysis of oncogenic noncoding RNAs. We utilize a multidisciplinary approach that integrates biochemical, biophysical, and structural biology techniques—including NMR spectroscopy, X-ray crystallography, and cryo-electron microscopy—to explore RNA structure–function relationships and identify opportunities for RNA-targeted therapeutic intervention in cancer and related diseases.

This position offers an exciting opportunity for candidates passionate about cutting-edge RNA biology and structural biology, with the potential to develop novel experimental approaches and lead research projects in a collaborative and well-resourced environment

Primary Responsibilities  

• Design and execute experiments to investigate the structure and dynamics of noncoding RNAs using biophysical and structural techniques (e.g., NMR, X-ray crystallography, cryo-EM)
• Conduct biochemical assays to study RNA-protein and RNA-small molecule interactions
• Perform in vitro transcription, RNA purification, labeling, and structural probing
• Analyze experimental data, interpret results, and contribute to manuscript preparation
• Present research findings at lab meetings, institutional seminars, and scientific conferences
• Mentor graduate students and contribute to training and scientific development within the lab
• Assist with the development of grant proposals and collaborative research initiatives
• Coordinate research study activities; lead and manage projects.
• May oversee the work of laboratory personnel, including training and development as well as daily work direction/delegation/prioritizing.

• Other duties as assigned. 

Knowledge – Skills – Abilities 

• Knowledge of structural biology, protein expression and purification, and molecular biology.
• Structural biology software: Phenix, Coot, Chimera, CryoSPARC, Relion
• Data utilization, complex problem solving, critical thinking, resource management, and writing skills
• Hands-on experience in X-ray crystallography or cryo-EM
• Experience in small molecule drug discovery and structure-based drug design
• Proven ability to work independently, manage time effectively, and troubleshoot experiments
• Excellent written and verbal communication skills

Qualifications 

Appropriate experience may be substituted for education on an equivalent basis.  

Minimum Required Education:        PhD in a scientific field - in Biochemistry, Biophysics, Structural Biology, Chemistry, Molecular

Minimum Required Experience:        

 Preferred Experience: 5 years of research experience               

• Experience in protein expression, purification, and RNA–protein complex reconstitution
• Exposure to small-molecule screening and
• medicinal chemistry
• Strong publication record in peer-reviewed journals

Physical Requirements 

Work requires occasionally lifting moderate weight materials, standing, or walking continuously. 

Work Environment 

Occasional exposure to dust, noise, temperature changes, or contact with water or other liquids. Work is performed in an environmentally controlled environment. 

Sensory Acuity 

Ability to detect and translate speech or other communication required. May occasionally require the ability to distinguish colors and perceive relative distances between objects. 

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Why MCW?

• Outstanding Healthcare Coverage, including but not limited to Health, Vision, and Dental. Along with Flexible Spending options

• 403B Retirement Package

• Competitive Vacation and Paid Holidays offered

• Tuition Reimbursement

• Paid Parenta