Senior Scientist, Immunology, In Vivo Pharmacology

Working with Us
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The Immunology and Cardiovascular Thematic Research Center (ICV TRC) at BMS is one of the fundamental Research units delivering therapeutics to patients. Our mission is to create transformative medicines of tomorrow based on the cutting-edge science of today. We leverage BMS’s internal invention engine that includes industry-leading expertise in small molecule chemistry, protein biotherapeutics, cell therapy, protein degradation, nucleic acids, and other therapeutic modalities.

Position Summary:

Located at the Cambridge Crossing site in Cambridge, MA, Bristol Myers Squibb is seeking a Senior Scientist, In Vivo Pharmacology, who will be conducting vivo research in the field of autoimmune diseases. This individual will interact seamlessly with other scientists and functional groups within a drug discovery team to formulate and implement the in vivo strategy for the programs in the Immunoscience Portfolio. While the major focus of this position will be the in vivo evaluation of novel therapeutic agents that will support these drug discovery efforts, additional responsibilities include the identification and validation of novel disease and target specific biomarkers, and the development of new pharmacodynamic and disease models for autoimmune indications. Other responsibilities include but are not limited to prepare, review and deliver scientific presentations to internal and external stakeholders; interact with senior management and key opinion leaders.

Position Responsibilities:

• Develop therapeutic hypotheses for autoimmune disease(s) based on literature discoveries, in vitro experimental data, in vivo animal modeling, immunological evolution, genetics, clinical data, and technological advances. 

• Collaborate alongside a cross-functional team to discover new targets, derive new biological mechanistic insights, and support in vivo pharmacology needs for programs as they move through clinical development. 

• Identify and implement appropriate PK/PD and disease models to support clinical candidate selection, human dose projection, biomarker identification, and life cycle management.

• Contribute to portfolio strategy discussions and foster external collaborations to advance program objectives.

• Communicate scientific findings effectively across multidisciplinary teams and to leadership.

• Mentor members of the Immunology in vivo Pharmacology team, providing scientific and strategic direction.

• Travel will be less than 5% of the time. 

Basic Qualifications:

• Bachelor’s Degree

  • 7+ years of academic and / or industry experience

Or

• Master’s Degree

  • 5+ years of academic and / or industry experience

Or

• Ph.D. or equivalent advanced degree in the Life Sciences

  • 2+ of academic and / or industry experience

Preferred qualifications:

• A Ph.D. with at least 2 years of post-graduate training or industry experience in the field of biology, immunology, or related scientific discipline.

• Research experience in the Immunology/Inflammation therapeutic area, with a strong in vivo background.

• Prior hands-on experience with animal models of autoimmune diseases is highly desirable.

• Comprehensive understanding of PK/PD assessments and proven experience designing ex vivo studies for pharmacodynamic and target engagement endpoints.

• A track record of scientific accomplishment.

• A sophisticated understanding of experimental design and the ability to identify