Senior Scientist II, Group Lead

 

Join our team of pioneers!

Based in Cambridge, MA and Gaithersburg, MD. We are committed to improving the health of people worldwide with our fundamental research and our work in the area of development of immunotherapies utilizing the full potential of the immune system to fight cancer, infectious diseases and other serious diseases. We believe in scientific rigor, innovation and passion as driving forces. BioNTech was founded by scientists and physicians to translate science into survival by combining fundamental research and operational excellence.

With decades of deep immunology expertise and experience in developing and optimizing mRNA as part of its broad suite of novel technologies, the company is working with the global community to defeat life-threatening and serious diseases such as cancer, COVID-19, malaria and tuberculosis. The first ever approved mRNA vaccine was created in the labs of BioNTech in Mainz, Germany. A fully integrated immunotherapy powerhouse. We remain focused on bringing our broad pipeline of next-generation immunotherapies and vaccines to people around the world to address cancer, infectious diseases, as well as a growing list of other medical conditions. To accomplish this, we continue to be deeply rooted in science and academic research while also having built a fully integrated, global immunotherapy company with cGMP and GMP manufacturing facilities anchored around deep expertise in immunology and complemented by an expanding set of capabilities.
 

 

Senior Scientist II, Group Lead

 

Position Summary

BioNTech US is seeking a creative, passionate, and curious Group Leader to join the Proteomics group and lead a team focused on advanced mass spectrometry-based applications for translational research. The successful candidate will work independently and as a strategic contributor on cross-functional teams to help pioneer and establish new technologies and workflows to advance preclinical validation of individualized cancer vaccines for oncology (IVAC) and vaccine development for infectious disease programs. Furthermore, the successful candidate will apply proteomics methodologies to support other therapeutic modalities such as antibody drug conjugates (ADCs). Leading a team as part of the Proteomics unit at BioNTech US, the successful candidate will interact with a cross functional group of scientists with the goal of establishing and applying advanced Proteomics workflows for exciting, translational research.

 

Primary Responsibilities

• Lead a team in Proteomics sample processing techniques for nanoLC-MS/MS analysis, including enzymatic digestion, desalting, chemical modification, and fractionation
• Collaborate and strategize with scientists across cross-functional teams to appropriately apply MS-based proteomics for preclinical validation across portfolios within BioNTech
• Lead a team in the optimization and execution of immunopurification and other affinity-based enrichment strategies
• Oversee generation of biological samples via mammalian cell culture
• Method development and implementation of protein purification strategies for isolation of membrane and intracellular proteins from cells and tissues
• Contributions to nanoLC-MS/MS experimental design
• Review of scientific literature and collaboration with cross-functional teams
• Tracking and compiling of results in an electronic notebook
• Assisting with training of lab personnel
• Analysis and presentation of results to cross-functional teams

Requirements: 

• PhD degree in proteomics, biology, chemistr