Senior Scientist - Cardiometabolic Disorders

Career Category

Job Description

Join Amgen’s Mission of Serving Patients

At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do.

Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.

Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

Senior Scientist - Cardiometabolic Disorders

What you will do

Let’s do this. Let’s change the world. The Department of Cardiometabolic Disorders is currently seeking a dedicated scientist to contribute to our research efforts in developing new treatments for cardiometabolic diseases. This role requires a commitment to developing a deep understanding of the pathogenic mechanisms that underlie obesity. In this vital role, you will be driving discovery efforts to identify how Amgen’s innovative biological modalities can improve the lives of patients who suffer from heart failure and related co-morbidities.

Key Responsibilities:

• Identification of new therapeutic targets and preclinical validation. The candidate is expected to be continuously aware of scientific developments in cardiometabolic disease, with an emphasis on obesity.
• Work collaboratively with a team of expert cardiometabolic scientists.
• Present research discoveries to colleagues and scientific meetings (oral or poster presentations and publish scientific papers in peer-reviewed journals).
• Lead ethical, high-quality research experiments in accordance with regulatory agencies and compliance guidelines.
• Design or assist in the development of medium to low-throughput assays used to support both small and large molecule drug development programs.
• Design and implement in vitro, ex vivo. It is critical that the candidate is familiar with the pathophysiology of heart diseases and related co-morbidities.
• Independently design, perform, and analyze laboratory experiments, including troubleshooting, optimization of assays, data collection, interpretation, biostatistical analysis, and presentation.
• Participation in cross-functional drug development teams as a key intellectual and technical contributor.
• Function optimally in a team-based or collaborative environment as part of a highly integrated team, possess excellent organizational, verbal, and written communication skills, and demonstrate the ability to produce reliable and reproducible results.

What we expect of you

We are all different, yet we all use our unique contributions to serve patients. The dynamic professional we seek is a technically adept scientist with these qualifications.

Basic Qualifications:

Doctorate degree PhD OR PharmD OR MD [and relevant post-doc where applicable]

Or

Master’s degree and 3 years of relevant experience

Or

Bachelor’s degree and 5 years of relevant experience

Preferred Qualifications:

• PhD with a degree in biology or a related discipline.
• 5 or more years of experience in cardiometabolic research in industry or academic settings.
• Willing to work in a team environment and possess good laboratory documentation skills.
• Postdoctoral research experience.
• Ability to perform in vitro assays to dissect the mechanism of action of therapeutic molecules in cardiac myocytes, fibroblasts, adipocytes, endothelial cells, and other relevant cardiac cell types.
• In vitro experience with cultured cell lines, siRNA transfection techniques, western blotting, quantitative PCR techniques, RNA/DNA isolation, laboratory automation, high-content imaging technology, and fluorescence microscopy.

What you can expect from us

As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we’ll support your journey every step of the way.

The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.

In additio