Scientist/Sr. Scientist, Medicinal Chemistry

tl;dr

General Proximity is a seed-stage startup developing the next generation of induced proximity medicines (IPMs). Our OmniTAC drug discovery engine furnishes molecules that co-opt existing cellular machinery to overcome therapeutic challenges, which have remained unapproachable to other modalities for decades.

We are seeking a first-rate medicinal chemist to help us pioneer this uncharted frontier of drug discovery.

Our Story

A long-standing challenge in drug discovery is the development of molecules capable of modulating difficult or "undruggable" targets. Disease-causing proteins can be dysfunctional in many different ways, but our armamentarium for fixing them is quite limited. The most common mechanism of action for FDA-approved drugs is inhibition[1], but there are many other possible perturbation types whose potential remains unrealized.

General Proximity is a seed-stage drug discovery company developing a novel platform technology to solve this problem. We make bifunctional drugs that induce the modification of drug targets by existing cellular machinery (rather than through direct modulation by the drug, the classical approach).

Historically, the development of technologies that allow one to push new buttons in biology has been an incredibly fertile field for the discovery of new medicines[2, 3, 4], and our technology holds the same promise.

 

The Position

We are seeking an experienced medicinal chemist with chemical biology training to be a founding member of our Chemistry/Drug Discovery Team. In this position, you will work with both our Chemistry and Platform Teams in the development of our core drug discovery technology and the generation of a completely novel class of therapeutics.

Your responsibilities will include: supervising synthetic efforts with our CROs, performing and analyzing in cellulo assays, designing and optimizing first-in-class bifunctional molecules, collaborating with our Drug Discovery and IP team on patent applications, providing input for mechanistic studies on lead drug molecules, and spearheading forays into new disease areas.

 

About You

High Agency. Initiative, independence, and self-accountability are some of our most valued traits.

Enthusiastic. We love people who are excited about what they are doing and are generally attempting to build a high-energy team.

Intensity and Grit. Early-stage startups are hard. Drug discovery is doubly so. We are looking for candidates who have a demonstrated ability to stick with complex problems for the long haul, with a team that has your back along the way.

Prosocial. We are here to create life-saving medicines for the patients who need it most. You should be, too.

 

Qualifications & Nice-To-Haves

• PhD in Medicinal Chemistry, Chemical Biology, Pharmacology, or related field.
• Industry experience is desirable, but the ability to work hard and learn fast is more important to us.
• Deep understanding of small-molecule drug discovery and its relationship to human disease.
• Applicant must be able to work fluently at the interface of chemistry and biology.
• Top-notch written and oral communication skills.

• Strong experience with:
  • Designing, synthesizing, and optimizing induced proximity medicines (e.g. PROTACs or other IPMs)
  • Contributing to hit-to-lead and lead optimization studies
  • Med-chem optimizations: SAR, PK/PD, strong understanding of DMPK
  • Applicant must have experience with chemical biology techniques such as mammalian cell culture and cell-based assays (e.g., cytotoxicity assays, transfections, stable cell line generation, co-immunoprecipitation), PPI assays (e.g., BRET, APEX/BioID, AlphaScreen), or strong experience in computational chemistry
    

• Nice to have:
  • Proficiency in HTS and phenotypic assay developme