Global Chief Medical Officer

Legend Biotech is a global biotechnology company dedicated to treating, and one day curing, life-threatening diseases. Headquartered in Somerset, New Jersey, we are developing advanced cell therapies across a diverse array of technology platforms, including autologous and allogenic chimeric antigen receptor T-cell, T-cell receptor (TCR-T), and natural killer (NK) cell-based immunotherapy. From our three R&D sites around the world, we apply these innovative technologies to pursue the discovery of safe, efficacious and cutting-edge therapeutics for patients worldwide.  

Legend Biotech entered into a global collaboration agreement with Janssen, one of the pharmaceutical companies of Johnson & Johnson, to jointly develop and commercialize ciltacabtagene autolecuel (cilta-cel). Our strategic partnership is designed to combine the strengths and expertise of both companies to advance the promise of an immunotherapy in the treatment of multiple myeloma.

Legend Biotech is seeking a Global Chief Medical Officer as part of the Clinical Development team based in Somerset, NJ. 

Role Overview

Legend Biotech is a global, integrated cell therapy company dedicated to discovering, developing, and manufacturing transformative therapies for patients with cancer, autoimmune, and other serious diseases. The company has a vision of harnessing the power of the immune system to create durable and potentially curative treatments. By combining deep scientific expertise with advanced manufacturing and global execution capabilities, Legend Biotech aims to change the way the world treats disease and to make cutting-edge cell therapies broadly accessible to patients.

Legend Biotech is at the forefront of cell therapy research and development. In pursuit of cure, the company is leveraging its integrated autologous, allogeneic and in vivo cell therapy platforms to design and deliver therapies that can reprogram immune cells to precisely target and eliminate the root cause of diseases, including cancers and autoimmune diseases.

Legend Biotech is recruiting an accomplished drug developer and a visionary organization/business leader as Global Chief Medical Officer (CMO) who will serve as the senior clinical development leader for our ongoing clinical programs and teams in both the United States and China. This role is pivotal in overseeing the global clinical development strategy, ensuring the safety, efficacy, and regulatory compliance of the company’s innovative therapies, and shaping the clinical vision for the company’s pipeline.

Reporting to President of Research and Development, the Global CMO will work closely with the executive leadership team, regulatory authorities, and key external stakeholders to lead the clinical development program from pre-clinical stages through to post-market activities. Additionally, the Global CMO will act as a strategic thought leader in the field of cell and gene therapy and provide clinical expertise in the design, execution, and interpretation of clinical trials, regulatory submissions, and product commercialization.

This position offers a unique opportunity to join a growing and innovative company at the forefront of cell and gene therapy, where the Global CMO will have the opportunity to make a profound impact on the future of medicine and improve patient outcomes globally.

Key Responsibilities  

•  Clinical Strategy & Leadership:
  • Lead the global clinical development strategy and execution for the company’s pipeline, ensuring alignment with corporate goals, market needs, and scientific advancements.
  • Oversee clinical trial design and execution, including Phase I-IV studies, for cell therapy products, ensuring rigor in scientific, regulatory, and clinical outcomes.
  • Provide strategic direction and operational management for clinical teams across the US and China, including medical, scientific, pharmacovigilance, clinical operations, site management, biometrics, and data integrity.
  • Act as a key clinical resource in interactions with regulatory agencies (FDA, EMA, NMPA), ensuring adherence to regulatory requirements in both US and China.
• Team Development & Collaboration:
  • Build and lead a high-performing, cross-functional clinical development team across multiple geographies, fostering a culture of collaboration, excellence, and scientific rigor.
  • Provide mentorship and leadership to clinical development teams, fostering professional development and ensuring alignment with organizational goals.