Scientist II, Process Science & Research Core

Who You Are

In this role, the Scientist will be responsible for experiments to inform AAV construct design and selection in our Process Science and Research Core department. The scientist is responsible for planning and executing experiments to optimize production of plasmid DNA and AAV Vectors for research applications. The Scientist will have a working knowledge of early development of AAV gene therapy vectors from construct design through candidate selection. Job level is commensurate with experience.

How You Contribute

• Plan and execute experiments to optimize molecular components of DNA and rAAV vectors
• Design and lead research projects to improve the production of research grade plasmid and vector 
• Design, execute and interpret early-stage rAAV vector screening experiments for construct optimization/selection and development of molecular tools for rAAV production
• Design, execute and interpret experiments to better understand how AAV biology contributes to rAAV production 
• Collaborate with Research, Process Development, and Analytical Development teams to implement experimental design changes and support internal research and program vector needs
• Support lab operations, including inventory management, solution preparation, and standard lab tasks
• Follow, propose improvements, and troubleshoot current laboratory protocols and operations 
• Maintain accurate records and thoroughly document work through data entry into electronic laboratory notebooks, with minimal supervision
• Prepare, organize, and track sample inventory during production and storage
• Perform additional lab tasks as assigned

What You Bring to the Team

Education & Experience

• PhD preferably in Science, Biotechnology, Engineering or other related field and 2+ years of hands-on lab experience in an industry setting OR
• Master’s degree preferably in Science, Biotechnology, Engineering or other related field and 5+ years of hands-on lab experience in an industry setting
• 2+ years of experience in design and evaluation of plasmids and molecular tools required for rAAV production

Competencies

• Expertise in  gene therapy construct design and optimization is highly preferred
• Hands on experience with mammalian cell culture and upstream rAAV production process is required
• Hands on experience with research grade plasmid production and QC is required
• Ability to learn and perform methods utilized in downstream purification of rAAV including ultracentrifugation and chromatography
• Knowledge and hands-on experience utilizing proper lab technique while working with biologics (ex. bacterial or mammalian cultures, proteins, plasmid DNA, viral vectors)
• Highly self-motivated, organized, and detail-oriented, with proven ability to foster strong relationships with other team members and stakeholders

Working Conditions and Physical Demands

• Work is normally performed:   in laboratory environment  
• Lifting requirements:   Under 20 lbs
• Travel requirements:   None
• Must have flexible work hours, and be willing to work outside of normal, scheduled hours; as necessary

About Kriya 

Kriya is a biopharmaceutical company whose mission is to develop life-changing gene therapies for diseases affecting millions of patients around the world.

We leverage our proprietary computational engine, in-house manufacturing infrastructure, and integrated design platform to engineer technologies and therapeutics with the potential to transform the treatment of a broad universe of diseases of high unmet need, with a focus on metabolic disorders, neurology, and ophthalmology.

What We Offer

Medical, Dental and Vision with 100% employee premium coverage ∙ Retirement matching ∙ Short and long-term disability benefits ∙ 12 company paid holidays ∙ Generous Time Off ∙ Cyber Safety protection ∙ EAP ∙ Company paid life insurance ∙ Equity ∙ and more!

Kriya is an equal opportunity employer. We celebrate diversity and are committed to creating an inclusive environment for all employees.

All job requirements in the job description provided indicate the minimum level of knowledge, skills, and/or abilities deemed necessary to perform the job competently. Job descriptions are an overview of the duties, responsibilities, and requirements of the position. Employees may be required to perform other job-related assignments as requested.