Senior Scientist, Biologics Generation & Analytics

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Job Description

Job Description

About the role:
The Research Senior Scientist is responsible for managing and performing scientific research, development, and testing of new products, manufacturing processes, and raw materials. This role aims to advance scientific knowledge and contribute to therapeutic advancements, aligning with Takeda's mission to deliver Better Health and a Brighter Future to people around the world.

How you will contribute:

• Design biologics with extensive experience in molecular biology
• Design DNA constructs for Chimeric Antigen Receptors and TCRs
• Reformat protein/antibody workflows for expression and engineer solutions for multispecifics and innovative non-antibody fusions.
• Design DNA constructs for protein expression of antibodies, single domains, multispecifics, enzymes, membrane proteins, etc. in transient expression constructs or for lentiviral transduction in stable cell line generation or chimeric antigen receptor expression
• Independently set up high throughput cloning and automation to assemble and generate DNA constructs to advance protein generation for multiple projects across many therapeutic areas. Contribute to multiple projects, being a senior scientific consultant and guide the teams on which isoforms are relevant for target design.
• Manage large projects or processes with limited oversight from the manager
• Coach, review, and delegate work to lower-level professionals
• Provide leadership by mentoring junior scientists and leading research projects
• Collaborate across various scientific disciplines to achieve research objectives
• Make recommendations concerning the acquisition and use of new technological equipment and materials

Skills and qualifications:

• PhD degree in a scientific discipline, Molecular Biology, Biochemistry, Biology, Bioinformatics etc., with 3+ years experience , or MS with 9+ years experience, or BS with 11+ years experience 
• In-depth experience with biologics and novel antibody designs and applying knowledge to drug discovery projects.
• Extensive experience in molecular biology and reformatting protein/antibody workflows for expression and experience designing engineering solutions (multispecifics and innovative non-antibody fusions) for projects.
• Experience in intellectual property aspects as related to design and is experienced with bioinformatics approaches and algorithms that aid design.
• Familiarity with biologics workflows and ability to design new vector formats.
• Expertise in different molecular biology databases at NCBI, Uniprot, etc., and multiple molecular biology software tools, such as Geneious Prime and Biologics, Genedata Biologics, Snapgene
• Advanced proficiency in molecular biology, capable of executing and optimizing complex techniques like gene cloning.
• Demonstrates leadership by mentoring junior scientists and leading research projects.
• Effective collaborator with ability to work across various scientific disciplines.
• Strong project management skills, able to lead projects from conception through to completion.
• Problem solver, capable of addressing and overcoming research challenges.
• Innovative thinker with a track record of applying new ideas to solve scientific problems.
• Excellent communication skills, adept at presenting complex data to diverse audiences.
• Committed to advancing scientific knowledge and contributing to therapeutic advancements.
• As an expert professional within the organization, you develop innovative solutions to complex problems aligned with organizational objectives. Your work involve