Biotransformation Senior Scientist (Early Oncology R&D)

Job Role: Biotransformation Senior Scientist (Early Oncology R&D) 

Location: Waltham 

The Oncology Drug Metabolism and Pharmacokinetics (DMPK) department  

Do you have a passion for Biotransformation and DMPK science, applied to Cancer biology? 

Would you like to apply your expertise to impact the lives of patients in a company that follows science and turns ideas into life changing medicines? Then AstraZeneca is the organization where you can make that happen! 

About AstraZeneca 

AstraZeneca is a global, science-led, patient-focused biopharmaceutical company that focuses on the discovery, development and commercialization of prescription medicines for some of the world’s most serious diseases. But we’re more than one of the world’s leading pharmaceutical companies. 

A place built on courage, curiosity and collaboration – we make bold decisions driven by patient outcomes. Empowered to lead at every level, free to ask questions and take calculated risks that write the next chapter for our pipeline and Oncology team. 

Oncology R&D is a major focus area and growth platform at AstraZeneca. Our vision is to be at the forefront of developing the new generation of cancer therapies. We work together across all boundaries to have a positive impact in the world by solving complicated problems. 

Business Area 

Be part of fulfilling our ambition to be world leaders in Oncology. We are already the fastest growing team within AstraZeneca and across the industry, and there are countless new indications and targets in our innovative pipeline. We deliver this value through launch excellence, commercial effectiveness and maximizing the lifecycle. By leveraging our commercialized portfolio, we are confident we can change the practice of medicine and redefine cancer treatment. 

The Oncology Drug Metabolism and Pharmacokinetics (DMPK) department provides ADME/DMPK, as well as translational PKPD Modeling & Simulation support to our portfolio. We are looking for an individual who has a passion for Biotransformation and DMPK science, applied to Cancer biology. 

The Biotransformation senior scientist reports to the Director of the DMPK ADME Group in Boston. In this role, the Biotransformation specialist determines major metabolic pathways by interpretation of mass spectra in biological matrices, reports data to project teams and other customers, determines the structures of metabolites using high resolution accurate mass spectrometry, identifies potentially genotoxic, reactive or active or metabolites, and highlights them to customers. The Biotransformation specialist contributes via the DMPK design leader (DDL) to the design of compounds with better properties (metabolic stability/metabolism pathways) via a detailed understanding of the mechanism responsible on a molecular level and is responsible for planning and suggestion of in vivo metabolism studies. This role is also responsible for elucidating the biotransformation pathways in humans and animals for compounds in development, including contributing to the regulatory documentation. 

The role holder will contribute to Oncology DMPK by: 

• Designing and executing biotransformation studies to assess metabolic pathways, soft-spot identification, structural elucidation and bioactivation potential of drug candidates.