Principal Medical (Science) Director - Neuroimmunology, Multiple Sclerosis

A healthier future. It’s what drives us to innovate. To continuously advance science and ensure everyone has access to the healthcare they need today and for generations to come. Creating a world where we all have more time with the people we love. 

The Opportunity

At US Medical (USM), we focus on broadening opportunities for patient access by ensuring that health care stakeholders have the evidence they need on our products and the confidence in that evidence to make informed treatment decisions. As a key pillar in the broader Genentech organization, USM has a pivotal role in bridging internal partner functions (including Research, Product Development, Commercial, and Government Affairs) and collaborating across the dynamic health ecosystem to ultimately deliver better patient outcomes while making care more accessible and affordable for all.

We are seeking a visionary medical leader to join the US Medical team at Genentech, focusing on Multiple Sclerosis (MS) and related disorders.  The Principal Medical Director is a player/coach to a team of Medical Directors (MD)/ Medical Science Directors (MSD) and will report to the Therapeutic Area Lead.  By putting patients and science at the center of all actions, they drive and guide medical strategy and tactics aimed at maximizing medical progress. They will play a critical role to establish and maintain professional relationships with key medical experts in their field and will oversee all aspects of medical product support including collaboration with the relevant stakeholders to drive timely data generation and dissemination. They are expected to maintain an in-depth understanding of the medical strategy and relevant clinical and payer issues, while ensuring Genentech's partners understand key trends and shifts in the external healthcare landscape. They understand and evaluate their team and organization’s opportunities and constraints and build capabilities with an enterprise mindset. They serve as the guardian for high standards of compliance, ethics and safety.

Key Responsibilities

• Strategic Leadership: Co-own and execute the medical value proposition and clinical strategies for the MS pipeline, ensuring tactics are aligned with the evolving US healthcare landscape and global Roche goals.

• Evidence Generation: Drive the design, execution, and monitoring of high-quality Phase IIIb/IV clinical trials, investigator-initiated research, and health economic data analysis to close knowledge gaps.

• Stakeholder Engagement: Build and maintain professional partnerships with therapeutic area experts, professional societies, and payers to facilitate scientific exchange and collaborative medical progress.

• Cross-Functional Collaboration: Represent the US Medical function within internal matrix teams and global global organizations, providing clinically meaningful perspectives for regulatory and scientific communications.

• People Development & Coaching: Act as a player/coach to inspire high performance, identifying development needs and fostering a culture of trust, inclusion, and empowered decision-making.

• Compliance & Safety: Serve as the guardian for high standards of ethics and safety, ensuring all medical communications and activities strictly adhere to Genentech-Roche policies.

• Tactical Execution: Lead the efficient implementation of medical tactics, including medical content development, clinical training, and insights generation, while prioritizing work in a fluid, resource-aware environment.

Who You Are

Qualifications & Experience

• Advanced Clinical/Science Degree required (e.g. PharmD, PhD, MD etc.) in Neuroimmunology

• 5+ years of pharmaceutical / biotechnology industry experience

• Experience in drug development (Phase I-IV), medical writing, and data analysis, with a thorough understanding of US regulatory/FDA requirements.

• Demonstrated ability to coach, mentor, and develop leaders, and to build relationships with and identify the needs of patients, providers, and payers.

• Substantive understanding of corporate legal and compliance, including GCP, OIG, and other guiding elements of the business.

• Proven track record of collaborating, coaching, and influencing outcomes in complex organizations and projects, embracing an agile mindset and new digital healthcare landscapes to serve patient needs.

Preferred Qualifications & Experience

• Extensive experience in Mult