Principal Research Scientist I, Cell Line Engineering

Company Description

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas – immunology, oncology, neuroscience, and eye care – and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on X, Facebook, Instagram, YouTube, LinkedIn and Tik Tok.

Job Description

Discovery Biotherapeutics and Genetic Medicine at Abbvie is seeking a highly motivated Principal Scientist with a strong understanding of therapeutic discovery and target-overexpressing (OE) stable cell line development to lead the Cell Line Engineering team at the AbbVie Bioresearch Center (ABC). The ABC site, based in Worcester, MA, offers a unique setting where Biologics drug discovery, development and manufacturing coexist in one location. In this position, the leader will be responsible for construct development, mammalian cell line engineering, characterization and stability testing, single cell cloning, as well as enhancement of platform processes.  Experience with high throughput cell line development, automation and PLM implementation for process optimization are preferred.

Job Responsibilities:

• Executes and guides the development and characterization of construct designs and stable target-OE or KO cell lines empowering all stages of Discovery research.
• Identify and implement advanced technologies strategically to develop stable target-OE cell lines, pools, and clones.
• Provide strategic, operational, and scientific guidance to the cell line engineering team.
• Conduct general laboratory research proficiently and independently, adapting and troubleshooting experimental designs and equipment to meet research requirements.
• Apply creative thinking to solve complex problems and promote new technologies, while effectively communicating mission and ideas to diverse audiences.
• The ideal candidate should be able to manage multiple projects across therapeutic disciplines within a dynamic and fast-paced team setting.

Qualifications

Qua