Scientist Protein Chemistry

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Job Description

Objective / Purpose:

We are seeking a highly skilled and motivated PhD level Protein Chemist to report into Takeda’s Structural Biology organization. The objective of this role is to support Takeda’s drug discovery programs by advancing the production, characterization, and structural elucidation of proteins critical to therapeutic research. As a member of the Structural Biology organization, this position will focus on designing, producing and characterizing proteins for biochemical assays, biophysical studies, and structure determination using methods such as x-ray crystallography or cryo-EM. The role involves both in-house protein production and characterization, collaboration with external contract research organizations, and engagement with internal experts and cross-functional teams to achieve project goals.

Accountabilities:

                                                                                                                                                                                                  

• Plan and execute protein production campaigns for protein reagents and/or structural biology efforts in collaboration with structural biologists and protein chemists utilizing in-house protein production capabilities, equipment and database resources
• Analyze proprietary and public information to positively impact structure determination efforts, reagent or antigen protein production and characterization and/or antibody design, optimization and characterization
• Work collaboratively and communicate clearly with interdisciplinary teams, including structural biologists, protein chemists, in vitro pharmacologists, medicinal and computational chemists, project management to advance pipeline projects
• Clearly communicate protein production and characterization plans, priorities, results and timelines to varied audiences

Education & Competencies (Technical and Behavioral):

• PhD degree in a scientific discipline (Structural Biology, Biophysics, Biochemistry/Enzymology, Protein Chemistry); MS with 6+ years or BS with 8+ years industry experience also considered; industry experience highly desirable
• Demonstrated track record of successful hands-on high-quality protein production (construct design, cloning, expression, purification, optimization, characterization) of protein reagents, antigens and/or antibodies or other biologics therapeutics for drug discovery teams  
• Experience in protein production utilizing contract research organizations highly desirable
• Success in design, expression and purification of membrane proteins and/or multi-protein complexes as well as knowledge of and/or experience in structural biology methodologies, biochemical and/or biophysical assays highly desirable
• Passion for learning and advancing protein production capabilities and drug discovery pipelines, including proactive investigation of new techniques and capabilities, advanced software / hardware and innovative experimental approaches
• Ability to work collaboratively in a fast-paced, matrixed environment with a collaborative and proactive mindset, motivated by a desire to create therapeutic molecules for the benefit of patients in need worldwide

Takeda Compensation and Benefits Summary

We understand compensation is an important factor as you consider the next step in your career. We are committed to equitable pay for all employees, and we strive to be more transparent with our pay practices. 

For Location:

Boston, MA

U.S. Base Salary Range:

$111,800.00 - $175,670.00

The estimated salary range reflects an anticipated range for this position. The actual base salary offered may depend on a variety of factors, including the qualifications of the individual applicant for the position, years of relevant experience, specific and unique skills, level of education attained, certifications or other professional licenses held, and the location in which the applicant lives and/or from which they will be performing the job.��The ac