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Senior Manager, Accounting

Definium Therapeutics
San Diego, USAfull_timePosted 1 Jun 2026

About the role

<div class="content-intro"><p>Definium Therapeutics is a late-stage clinical biopharmaceutical company and our mission is to forge a new era of psychiatry by applying scientific rigor to psychedelics, with the goal of developing accessible treatments that unlock healing at scale.&nbsp;&nbsp;</p> <p>Our lead&nbsp;product&nbsp;candidate,&nbsp;lysergide&nbsp;tartrate&nbsp;(our&nbsp;proprietary orally disintegrating tablet form of&nbsp;lysergide&nbsp;(LSD) D-tartrate),&nbsp;represents a highly differentiated, potential best-in-class opportunity for patients suffering from generalized anxiety, major depressive disorder, and posttraumatic stress disorder. Our early stage pipeline includes DT402, the R-enantiomer of MDMA and is under development to target the core symptoms of autism spectrum disorder (ASD), specifically addressing social communication challenges.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</p> <p>Guided by&nbsp;the recognition&nbsp;that patients deserve more than better, Definium is relentlessly advancing a new generation of therapeutics intended to address&nbsp;the&nbsp;underlying causes of psychiatric and neurological disorders. By turning evidence into impact, Definium aims to change the trajectory of today’s mental health care crisis and enable a healthier future. Headquartered in New York, Definium Therapeutics trades on Nasdaq under the symbol DFTX.&nbsp;</p> <p>Together we are moving psychiatry forward—beyond better, into a boundless future. Join us!</p></div><p>Reporting to the Corporate Controller, the <strong>Sr. Manager, Accounting</strong> will play a key role in our accounting team, with a strong emphasis on SOX 404(b) compliance and equity (stock-based compensation) accounting. This role will be responsible for designing, implementing, and maintaining internal controls, as well as overseeing the accounting and reporting for equity transactions in a fast-paced, public company environment.</p> <p><strong>Responsibilities</strong></p> <ul> <li>Oversee accounting for stock-based compensation, including stock options, RSUs, PSUs, and ESPP</li> <li>Ensure accurate and timely recognition of equity compensation expense in accordance with ASC 718</li> <li>Manage equity-related reports and data from Shareworks</li> <li>Review and validate fair value assumptions (e.g., Black-Scholes inputs, peer companies)</li> <li>Coordinate with Legal, HR, and external valuation specialists on equity grants and modifications</li> <li>Support preparation of equity disclosures for SEC filings (10-K, 10-Q, proxy)</li> <li>Help lead the design, implementation, and ongoing maintenance of internal controls in compliance with SOX 404(b)</li> <li>Partner with internal and exter

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Company

Definium Therapeutics

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