Medical Director, Pediatric Endocrinology – Medical Affairs

Rezolute is a late-stage rare disease biopharmaceutical company focused on developing transformative therapies for patients living with severe metabolic and endocrine disorders. Our lead investigational therapy, RZ358 (ersodetug), is a fully human monoclonal antibody in late-stage clinical development for the treatment of congenital and acquired forms of hyperinsulinism (HI). Rezolute’s mission is to bring hope and meaningful solutions to patients and families affected by rare diseases through scientific innovation, collaboration, and integrity

 The Medical Director, Pediatric Endocrinology – Medical Affairs will serve as Rezolute’s internal medical and scientific expert for hyperinsulinism and related endocrine disorders. This individual will play a pivotal role in developing and executing the Medical Affairs strategy for RZ358 and the company’s broader endocrinology portfolio.

This role will lead internal medical and disease-state education, support cross-functional launch readiness, and provide scientific leadership for engagement with specialty healthcare professionals (HCPs) and key opinion leaders (KOLs). The Medical Director will partner closely with the field-based Senior Medical Science Liaisons (MSLs) and cross-functional colleagues in Clinical Development, Regulatory, Commercial, and Market Access to ensure alignment, scientific rigor, and excellence across all medical activities.

Key Responsibilities

Medical Strategy & Leadership

• Partner in shaping and delivering Rezolute’s Medical Affairs strategy for RZ358 in congenital and acquired hyperinsulinism.
• Serve as the internal disease area expert for pediatric endocrinology and hyperinsulinism, providing strategic input into launch readiness, data generation, and scientific communication.
• Collaborate with Clinical Development and Commercial teams to ensure medical strategy supports both clinical evidence needs and market preparedness.
• Contribute to the development of publication plans, data dissemination strategies, and scientific platforms.
• Assist with integrating insights gathered from field interactions into Medical Affairs strategy, launch readiness plans, and scientific communication priorities.
• Partner with senior Medical Affairs leadership to ensure consistent messaging, training, and field alignment across all medical initiatives.

Internal Education & Training

• Equip internal teams with the knowledge and confidence to meaningfully engage the medical and patient community through targeted disease and product education. Function as the primary trainer for scientific and clinical content related to hyperinsulinism pathophysiology, RZ358 mechanism of action, clinical data, and competitive landscape. 
• Mentor and coach MSLs to enhance their scientific expertise and strategic engagement capabilities.

External Engagement & Thought Leader Collaboration

• Build and maintain strong, peer-to-peer scientific relationships with leading endocrinologists, pediatric endocrinologists, and metabolic disease experts.
• Support the identification, engagement, and development of key opinion leaders (KOLs) and other external experts in the HI community.
• Participate in and represent Rezolute at relevant endocrinology and rare disease congresses, advisory boards, and symposia to communicate emerging science and gather medical insights.
• Provide scientific leadership for investigator-initiated studies (IIS), data generation efforts, and collaboration opportunities focused on hyperinsulinism.
• Capture and synthesize medical insights from field teams and external experts to inform strategy, publications, and future development programs

Medical Affairs Execution

• Collaborate with field-based MSLs and cross-functional launch teams to execute medical education, data dissemination, and stakeholder engagement plans for RZ358.
• Assist with the development of standard response documents and support Medical Information system execution.
• Provide medical oversight for advisory board content, educational programs, and medical materials, ensuring scientific accuracy and compliance.
• Provide ongoing scientific support to the Medical Information function through drafting, review, and refinement of standard response documents and FAQs.
• Contribute to the development of scientific slide decks, FAQs, and other materials for internal and external use.

Compliance & Governance

• Ensure all Medical Affairs activities and communications comply with Rezolute SOPs, industry codes of practice, and regulatory standards.
• Support medical/legal/regulatory (MLR) and promotional review activities, serving as a medical reviewer for scie