Principal Scientist - Process Modelling

Job title: Principal Scientist - Process Modelling

Location: Framingham, MA

About the Job

Are you ready to shape the future of medicine? The race is on to speed up drug discovery and development to find answers for patients and their families. Your skills could be critical in helping our teams accelerate progress.

The Principal Scientist, Process Modelling will be based in the Global CMC Development group in Research & Development (R&D) and will provide process modelling and advanced analytics support for biological process development.  

With a formal training as a process systems engineer and a specialization in process modelling, you will have demonstrated skills in the field of mechanistic and hybrid modelling methodologies to support process design, optimization, and process control activities for biopharmaceuticals. You will also have familiarity with machine learning/data-driven modelling methodologies to support these applications. 

The main focus for this position will be on the development and deployment of process models for downstream unit operations such as chromatography columns, viral inactivation and filtration units (UF/DF and viral filtration). However, prior experience with modelling methodologies to support upstream unit operations (e.g. bioreactor modeling, media development/optimization) will be considered a plus. 

We are an innovative global healthcare company with one purpose: to chase the miracles of science to improve people’s lives. We’re also a company where you can flourish and grow your career, with countless opportunities to explore, make connections with people, and stretch the limits of what you thought was possible. Ready to get started?​

Main Responsibilities:

• As part of matrix project teams, develop and deploy mechanistic, hybrid and data-driven modelling solutions to support downstream and upstream process development activities for a broad range of biopharmaceuticals. 

• Use programming languages such as Python, MATLAB, R to translate complex mathematical models into clean and reusable codes for model use and implementation. 

• In coordination with the process development group and working closely with the Data Science team, design and analyze targeted experiments required to calibrate and verify model performance. 

• Act as a change agent to support the implementation of process modelling in established process development workflows for targeted downstream and upstream unit operations. 

• Track progress against deliverables and maintain a communication plan with key stakeholders and partners across departments. 

• Document your modelling work with rigorous scientific communication via technical presentations, reports and, when appropriate, scientific publications. 

About You

For this position, domain knowledge in biologics downstream process development and manufacturing is required. Familiarity with upstream unit operations is a plus. 

This is an exciting opportunity to <