Executive Director, Early Development

Working with Us
Challenging. Meaningful. Life-changing. Those aren’t words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You’ll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams. Take your career farther than you thought possible.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: careers.bms.com/working-with-us.

RayzeBio, a Bristol Myers Squibb company, is a dynamic biotechnology company headquartered in San Diego, CA. The company is focused on improving survival of people with cancer by harnessing the power of targeted radioisotopes. RayzeBio is developing innovative drugs against targets of solid tumors. Led by a successful and experienced entrepreneurial team, RayzeBio aims to be the global leader in radiopharmaceuticals.

The Executive Director, Early Development will provide leadership and strategic direction in developing RayzeBio’s portfolios from development candidate through early POC and Phase I/II studies. This role will work closely with research and translational medicine, engage across several solid tumor assets, and contribute to clinical development plans. The Executive Director may directly supervise the work of Early Clinical Development physicians, clinical scientists and medical physicists. The role will be foundational in working with teams in R&D to provide Clinical expertise from discovery through POC transitions, providing insights into biology, translational elements, as well as overall benefit-risk assessments. The role will report directly to the CMO, RayzeBio, and will be a member of the Clinical Development leadership team. 

Job Responsibilities:

Essential duties and responsibilities include the following.  Other duties may be assigned. 

Strategy & Execution 

• Oversees and/or designs and develops clinical studies and research plans in support of asset strategy with the research and clinical team; clinical studies include early human imaging studies, first-in-human Phase I, proof of concept Phase I/II, entry registrational studies, biomarker qualification studies, and/or clinical pharmacology studies   

• Strategic and technical management of multiple/complex active early development programs in partnership with research and translational medicine    

• Contributes to and participates in formal protocol review and provides approval as appropriate   

• Contributes to overall strategy for specific disease/indications while ensuring an overall portfolio view   

• Liaises with clinical leadership and upper management to define clinical strategy, including dose and schedule, indications, and patient selection (e.g., biomarker qualification and implementation)  

• Presents and/or articulates clinical strategy to senior leadership across the enterprise to support progression of portfolio    

• Leads search and evaluation activities on business development due diligence efforts, and provides advice to strategic transactions group   

• Participates in medical monitoring activities as needed for early-phase clinical trials and works with CROs engaged in the conduct of such trials 

Medical Monitoring 

• Oversees and/or serves as Medical Monitor for clinical trials from Phase 1 through Proof-of-Concept by Articulating and executing clinical development strategy  

• In collaboration with cross-functional teams, analyzes, interprets, and acts on emerging Clinical Trial data. 

• Serves as principal functional author for Regulatory submissions, study reports, and publications   

Leadership and Matrix Management   

• May be responsible for managing Clinical Development Physicians, scientists, and medical physicists  

• Champions a quality-focused mindset and ensures adherence to GCP and compliance obligations for clinical conduct   

• Establishes an effective and ethical culture that encou