Enterprise Programs - Senior Program Manager

Career Category

Information Systems

Job Description

Join Amgen’s Mission of Serving Patients

At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do.

Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.

Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

Enterprise Programs - Senior Program Manager

What you will do

Let’s do this. Let’s change the world. In this vital role you will lead strategic, business-driven technology initiatives that deliver measurable outcomes and business value. This role is ideal for a seasoned program leader with a strong understanding of both business processes and enterprise technology. You will oversee a portfolio of transformational initiatives aimed at enabling innovation, improving operational efficiency, and advancing data-driven decision making.

You will work in a global, matrixed environment and collaborate closely with cross-functional partners across business units, technology functions and external partners. A key focus will be on aligning technology delivery with business priorities, ensuring every program contributes to tangible, strategic outcomes. You’ll need a proven ability to translate vision into execution, manage change, and influence cross-functional stakeholders at all levels of the organization.

Key Responsibilities:

• Lead delivery of complex programs that align to enterprise goals and deliver measurable value!

• Drive transformational programs to deliver on business priorities

• Work closely with business stakeholders to define outcomes, ensure solutions are implemented as planned and drive adoption

• Translate business needs into executable program plans, including scope, timelines, resource planning, and budget oversight

• Partner with cross-functional teams including data & analytics, enterprise applications, and digital product teams to deliver outcomes

• Manage program governance, steering committees, and status reporting for senior partners

• Drive structured methodologies such as Agile, SAFe, or hybrid approaches to improve delivery efficiency and responsiveness

• Track program KPIs, ROI, and performance metrics aligned to business success criteria

• Coordinate organizational change, business readiness, and stakeholder engagement activities across functions and geographies

• Build trust and alignment across technology teams and business leaders to sustain long-term strategic partnerships

• Apply continuous improvement practices to program execution and delivery frameworks.

What we expect of you

We are all different, yet we all use our unique contributions to serve patients. The professional we seek will have these qualifications.

Basic Qualifications:

Doctorate degree and 2 years of Scientific and/or IT Operations and/or Business experience

Or

Master’s degree and 4 years of Scientific and/or IT Operations and/or Business experience

Or

Bachelor’s degree and 6 years of Scientific and/or IT Operations and/or Business experience

Or

Associate’s degree and 10 years of Scientific and/or IT Operations and/or Business experience

Or

High school diploma / GED and 12 years of Scientific and/or IT Operations and/or Business experience

Preferred Qualifications:

• 6–10 years of experience delivering business technology solutions and programs in a matrixed, global organization

• Demonstrated success in aligning technology execution with business strategy to achieve measurable outcomes

• Experience leading transformational programs or M&As

• Experience leading programs involving business process optimization, digital product rollouts, enterprise applications, or analytics platforms

• Proficiency with program and portfolio management tools (e.g., Smartsheet, JIRA, ServiceNow, Confluence) and executive reporting dashboards.

• Strong stakeholder engagement, communication, and