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Associate Director, Non-Clinical Research
Rhythm PharmaceuticalsUnited Statesfull_timeVerifiedPosted 19 Aug 2025
About the role
Company Overview
Rhythm is a global, commercial-stage biopharmaceutical company committed to transforming the lives of patients and their families living with rare neuroendocrine diseases. We develop medicines for previously untreatable or undertreated diseases and provide meaningful support for healthcare providers and patients and their families. We recognize the courage it takes for patients and their caregivers to begin their journey of advocacy to find the answers they need. Their courage inspires us to challenge convention, ask bold questions and seek answers for them. Every day, we strive for excellence through our willingness to adapt, learn, and our tenacity to overcome barriers, together.
Opportunity Overview
Rhythm Pharmaceuticals is seeking an Associate Director, Non-Clinical Research with demonstrable experience and expertise in small molecule drug discovery and non-clinical development to join the Rhythm research team. The successful candidate will have be involved in driving internal research and development activities critical to the advancement of the Rhythm product pipeline for neuroendocrine diseases. Responsibilities will include supporting the inception, design, operationalization, management and interpretation of non-clinical development studies and exploratory research activities that expand understanding of Rhythm pharmacological assets and indications. The efforts of this role will inform broader Rhythm translation and clinical activities and contribute to overall company strategy. This role will report into the Sr. Director, Non-Clinical Development.
Responsibilities and Duties
Qualifications and Skills
Rhythm is a global, commercial-stage biopharmaceutical company committed to transforming the lives of patients and their families living with rare neuroendocrine diseases. We develop medicines for previously untreatable or undertreated diseases and provide meaningful support for healthcare providers and patients and their families. We recognize the courage it takes for patients and their caregivers to begin their journey of advocacy to find the answers they need. Their courage inspires us to challenge convention, ask bold questions and seek answers for them. Every day, we strive for excellence through our willingness to adapt, learn, and our tenacity to overcome barriers, together.
Opportunity Overview
Rhythm Pharmaceuticals is seeking an Associate Director, Non-Clinical Research with demonstrable experience and expertise in small molecule drug discovery and non-clinical development to join the Rhythm research team. The successful candidate will have be involved in driving internal research and development activities critical to the advancement of the Rhythm product pipeline for neuroendocrine diseases. Responsibilities will include supporting the inception, design, operationalization, management and interpretation of non-clinical development studies and exploratory research activities that expand understanding of Rhythm pharmacological assets and indications. The efforts of this role will inform broader Rhythm translation and clinical activities and contribute to overall company strategy. This role will report into the Sr. Director, Non-Clinical Development.
Responsibilities and Duties
- Support/lead Rhythm’s non-clinical programs, in particular all drug discovery research activities from lead generation to IND and contribute to early clinical studies related to different programs.
- Support/lead and innovate the design, development, and execution of in vitro pharmacology assays and in vivo studies in animal models of disease to assess the biological activity, mechanism of action, and efficacy of novel therapies targeting primarily rare genetic obesity diseases and genetic metabolic disorders.
- Select and manage contract research organizations (CROs) to support non-clinical development programs
- Design and manage non-GLP and GLP pre-clinical studies (pharmacology, PK/PD, DRF, toxicology) conducted at different CROs for inclusion in IND filing or for possible new indications
- Exercise technical expertise in the design, execution of the studies, data analysis and interpretation of results that contribute/support project goals
- Provide expertise and guidance to other functional areas in the company to ensure that all non-clinical studies are performed in a timely manner and executed at high quality
- Prepare technical reports, quantitative analyses, protocols, and scientific presentations
- Communicate effectively to discuss project progress, interpret, and present data internally and externally at scientific meetings and conferences
- Actively support and pursue necessary external collaborations
- Support budget planning
Qualifications and Skills
- PhD or M.D./Ph.D. in neuroscience, metabolism, pharmacology, molecular biology, genetics or physiology preferred
- 5+ years of related experience in industry, including research experience in the pharmaceutical sector preferably in metabolic diseases and/or neurobiology
- Experience working with small molecules and/or biologics
- Extensive experience in the design, conduct and data analysis of in vitro pharmacokinetic assays and in vivo PK/PD experiments in different animal models of metabolic and genetic diseases of obesity
- Significant experience in managing CROs across the globe for preclinical discovery or translational studies and developing possible biomarkers for clinical studies
- Strong understanding of non-clinical safety toxicology program with experience in protocol and report preparation
- Solid knowledge of the pathogenesis of metabolic diseases across multiple indications, including rare genetic diseases of obesity, general obesity, diabetes, and rare genetic metabolic disorders and the application of cellular and molecular mechanisms and models to support program development/decisions<
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