Principal Scientist, Immunology

About Rezo TherapeuticsRezo is a different kind of biopharma company.  Our mission is to dramatically increase the success rate of drug development by building a disease-agnostic, fully-integrated, network biology platform that will redefine our understanding of human disease and ability to treat it.  
Our Founders and members of the Board are a group of esteemed, world-class scientists from the University of California, San Francisco: Nevan Krogan, Kevan Shokat, Sourav Bandyopadhyay, Natalia Jura, as well as renowned biotech executives George Scangos and Norbert Bischofberger. These leaders bring with them a strong track record of amazing discoveries and scientific breakthroughs, leading to very successful companies and many FDA approved drugs. 
Capitalizing on our Series A of $78M from top-tier investors, we are leveraging a unique integrated approach, combining capabilities in genetics, proteomics, structural biology and AI to generate deep biological insights and novel therapeutic approaches.
Located in San Francisco’s vibrant Mission Bay neighborhood, Rezo is in close proximity to UCSF, numerous urban amenities, and outdoor recreational opportunities. We recognize that realizing our mission depends as much on our people as it does on our science and are building a workplace that fosters collaboration, respect, and diversity where contributing to your team’s success is valued as highly as individual achievements.  If you’re passionate about team science and breaking down barriers to progress in drug development, please consider joining us! 
The OpportunityWe are hiring a Principal Scientist, Immunology to join Rezo’s Biology Team. In this role, you will collaborate with an interdisciplinary group combining genetics, proteomics, structural biology, and AI to tackle challenging biological questions and develop transformative therapies. This opportunity allows you to leverage your expertise in cancer biology and immunology to develop and execute cutting-edge cellular assays for target validation and compound screening. Joining Rezo at this stage provides a chance to make a meaningful impact in a fast-paced, collaborative environment.

Key Responsibilities:

• Optimize and develop assays to study immune cell signaling pathways in the context of inflammation and cancer.
• Develop, optimize, and perform immune phenotyping and functional assays, including multicolor flow cytometry (10+ colors), ICS, ELISpot, proliferation assays, and cytokine ELISA/MSD.
• Design and execute CRISPR-based genetic studies for target validation and mechanistic insights.
• Perform genetic manipulation of immune cells, using CRISPR/Cas9, siRNA, and lentivirus-based techniques, to evaluate target function and therapeutic potential.
• Analyze experimental data, interpret findings, and prepare reports for internal discussions, regulatory filings, and publications.
• Collaborate across interdisciplinary teams and effectively communicate scientific results.
• Manage multiple projects efficiently in a dynamic and fast-paced setting.

Qualifications:

• PhD in immunology, or a related field with relevant postdoctoral or industry experience.
• Candidates with a Master’s or Bachelor’s degree and extensive expertise in immune cell manipulation and assay development are also encouraged to apply.
• Expertise with flow-cytometry and phenotyping immune cells.
• Proficiency in genetic manipulation of immune cells, including CRISPR/Cas9, siRNA, and lentiviral technologies.
• Strong understanding of immune cell signaling pathways.
• Skilled in developing immune cell functional assays and phenotypic screening assays to screen small molecule drug candidates.
• Proven ability to work independently while fostering collaboration in a team environment.
• Excellent organizational, communication, and interpersonal skills.

Compensation at RezoThe expected starting salary range for this position based in San Francisco, California for a Principal Scientist is $150,000 - $210,000. Actual starting salary will be determined based on multiple job-related factors including a candidate’s skills, education, and experience, the level at which they are hired, market demand, business needs, and internal parity. This role is eligible for participation in our Annual Discretionary Bonus Plan (based on individual and company performance) and our Equity Incentive Plan, subject to the terms of those plans and associated policies. This position is also eligible for the benefits detailed below.

Benefits at RezoMedical (HMO or PPO), dental, and vision insuranceDiscretionary time off policyCompany holidays (including summer and winter shutdown)401(k) retirement savings programCommuter / Mass Transit Benefit ProgramHealthcare Flexible Spending Account (FSA)Dependent care Flexible Spending Account (FSA)P