Senior Advisor – Discovery ADME Project Leader

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.

Job Title: Senior Advisor – Discovery ADME Project Leader 

Organization Overview 

Lilly is a global healthcare leader headquartered in Indianapolis, Indiana. Our 50,000 employees around the world work to discover and bring life-changing medicines to those who need them. At Lilly, the Discovery Investigative ADME, Toxicology and BioAnalytical Research team focuses on pre-clinical discovery using cutting-edge science and technology approaches to treat diseases with poor treatment options. 

Position Summary 

We are seeking an experienced, accomplished drug hunter as a Discovery ADME Project Leader.  The ideal candidate will provide deep mechanistic understanding of drug disposition, PK, and translational science, plus the ability to integrate biology, chemistry, and modeling.  Experience with Small Molecule Discovery and in project teams with Beyond-Rule-of-Five and pan-modality chemo-types is advantageous.  The successful candidate will bring exceptional scientific depth and acumen as an integral member of the project team to create bold Target Product Profiles, help establish design strategy and expectations, partner globally and cross-functionally and ensure teams are advancing The Right Molecule to The Right Study at The Right Time (our three R’s). 

Geography for this position is open to Indianapolis IN, Louisville CO or Boston MA. 

What You Will Do 

• Keep Safety as a priority. 

• Develop and execute integrated preclinical ADME strategies aligned with discovery stage, target product profile (TPP), design hypotheses being tested, and regulatory expectations. 

• Integrate ADME and pharmacology to enable translational simulations and modeling to support dose selection, design of PK/PD, efficacy and safety studies. 

• Define stage-, modality-, and issue-appropriate screening, decision funnels (in silico, in vitro, in vivo to translational modeling). 

• Guide compound design and optimization through data-driven design principles (clearance, permeability, solubility, DDI risk, transporter liabilities). 

• Serve as the ADME strategy and science single-point-of-accountability on cross-functional program teams, translating ADME findings into actional design and test hypotheses. 

• Collaborate