Principal Scientist, Cell Therapy In Vivo Pharmacology

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Challenging. Meaningful. Life-changing. Those aren’t words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You’ll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams rich in diversity. Take your career farther than you thought possible.

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The In Vivo Pharmacology team in the Cell Therapy Thematic Research Center has an opening for a highly collaborative and creative Principal Scientist with a dedication to discovery and development of novel engineered immune effector cell therapeutics for the treatment of cancer and other chronic diseases. The successful candidate will have a strong immunology background, experience with a broad range of tumor models, and a desire to lead functional workstreams from early stages/target concept through to IND filing. This position is ideal for a motivated and interactive scientist who is passionate about cell therapy and has a proven track record working across highly matrixed teams to drive key decisions for drug discovery and development.

Position Responsibilities

In the role as a Principal Scientist within the In Vivo Pharmacology Team, the ideal candidate will:

• Lead functional workstreams on highly matrixed cell therapy research project teams from target concept to IND

• Mentor/supervise pharmacology team members to support in vivo experimentation, including planning and directing lab research

• Possess broad experience in the development and execution of tumor models, including syngeneic and xenograft models, and / or T cell-driven immune response models

• Demonstrate expertise in multi-parameter flow cytometry (10-plus colors), immune cell functional assays (e.g. proliferation, cytokine production, cytotoxicity), and the field of cellular immunology

• Independently author study reports, technical protocols, publications and documents to support regulatory and patent submissions, demonstrating broad experience in scientific writing

• Present complex concepts to a range of audiences including governance and departmental meetings

• Apply advanced technical knowledge to guide the development of cutting-edge immune cell therapies

• Excel in a fast-paced team environment, meet deadlines, and prioritize work on multiple projects while fostering open and productive scientific communication and collaboration

Experience =

Basic Qualifications:

• Bachelor’s Degree

  • 8+ years of academic and / or industry experience

Or

• Master’s Degree

  • 6+ years of academic and / or industry experience

Or

• Ph.D. or equivalent advanced degree in the Life Sciences 

  • 4+ years of academic and / or industry experience

Preferred Qualifications:

• Ph.D. or equivalent advanced degree in Immunology or related field 

• 6+ years of academic and industry experience

• Experience with preclinical assessment of therapeutic candidates including cell-based therapies, immunotherapies, and drug combination studies

• Knowledge of pharmacokinetic and pharmacodynamic models to evaluate candidate therapeutics

• Familiarity with gene editing technologies and delivery methods (e.g., adeno-associated viral vectors, non-viral delivery, CRISPR gene editing)

• Ability to write and manage IACUC protocols, own compliance with these and other protocols, and identify potential gaps

• Track record of successful internal and external scientific collaborations

• Experience supervising technical staff to lead early-stage projects

The starting compensation for this job is a range from $153,680 - $186,200, plus incentive cash and stock opportunities (based on eligibility). 

The starting pay rate takes into account characteristics of th