Senior Director, Commercial Systems

Zenas is a clinical-stage global biopharmaceutical company committed to becoming a leader in the development and commercialization of transformative therapies for patients with autoimmune diseases. Our core business strategy combines our experienced leadership team with a disciplined product candidate acquisition approach to identify, acquire and develop product candidates globally that we believe can provide superior clinical benefits to patients living with autoimmune diseases. Zenas is advancing two late-stage, potential franchise molecules, obexelimab and orelabrutinib. Obexelimab, Zenas’ lead product candidate, is a bifunctional monoclonal antibody designed to bind both CD19 and FcγRIIb, which are broadly present across B cell lineage, to inhibit the activity of cells that are implicated in many autoimmune diseases without depleting them. We believe that obexelimab’s unique mechanism of action and self-administered, subcutaneous injection regimen may broadly and effectively address the pathogenic role of B cell lineage in chronic autoimmune disease. Orelabrutinib is a potentially best-in-class, highly selective CNS-penetrant, oral, small molecule Bruton’s Tyrosine Kinase (BTK) inhibitor with the potential to address compartmentalized inflammation and disease progression in Multiple Sclerosis (MS). Zenas’ earlier stage programs include a preclinical, potentially best-in-class, oral, IL-17AA/AF inhibitor, and a preclinical, potentially best-in-class, oral, brain-penetrant, TYK2 inhibitor.

We are seeking top talent who share our commitment to patients and have a track record of success in acquiring, developing and commercializing products across the globe. Our colleagues have an opportunity to engage in a fast-paced learning environment and experience individual and organizational success as we work towards becoming a global immunology and autoimmune disease leader, while living our values of Transparency, Relationships, Urgency, Excellence and Innovation – TRUE Innovation!

Position Summary:

The Senior Director, Commercial Systems will serve as a strategic IT leader and business partner for Commercial, Medical Affairs, and Market Access organizations at Zenas BioPharma. Reporting to the Head of Information Technology, this role is responsible for developing and executing the commercial technology strategy and roadmap in preparation for Zenas’ first product launch and sustained commercial operations.

This individual will play a key role in the selection, implementation, integration, and ongoing management of the commercial technology ecosystem, including CRM, commercial data warehouse, master data management, marketing operations, field force technology, market access, and analytics platforms. The Senior Director will build deep partnerships with Commercial Operations, Sales, Marketing, Medical Affairs, Market Access, and Compliance stakeholders to position IT as a strategic enabler of commercial success.

This is a high-visibility role critical to Zenas’ transition from a clinical-stage company to a commercial organization. The ideal candidate has direct experience standing up commercial IT capabilities for a first product launch in a biotech or specialty pharma environment, is a subject matter expert in biopharma commercial processes and technology platforms, and thrives in a fast-paced, lean organization where both strategic thinking and hands-on execution are required.

Key Responsibilities:

Commercial Technology Strategy & Roadmap

• Develop the commercial technology strategy and multi-year roadmap aligned with Zenas’s launch timeline, brand strategy, and commercial operating model.
• Lead the end-to-end evaluation, selection process, and implementation of the commercial technology ecosystem, including CRM (e.g., Veeva CRM/Vault CRM), closed-loop marketing, content management, commercial data warehouse, and analytics platforms.
• Define the target-state commercial systems architecture, ensuring scalability, data integrity, and seamless integration across platforms and with other enterprise systems.
• Build and present business cases for commercial technology investments to medical and commercial leadership, aligning spend with strategic priorities and launch milestones.

Commercial Data, Analytics & Master Data Management

• Partner with Commercial Insights and Operations to architect and operate the commercial data warehouse, integrating data from CRM, claims/prescription data, specialty pharmacy, patient services, payer, and third-party data providers.
• Drive master data management (MDM) strategy for HCP, HCO, and customer data, ensuring data quality, governance, and alignment with downstream reporting and compliance requirements.
• Enable self-service analytics and business