Executive Medical Director, U.S. Medical Affairs

POSITION SUMMARY:

As Intercept continues to build its position as the leader in rare and serious liver disease, we are seeking visionary and strategic Executive Medical Director to lead the U.S. Medical Affairs efforts for Ocaliva, a flagship product in our portfolio. This role is pivotal in shaping the medical strategy across all aspects of the product lifecycle and driving transformative change in how we engage with science, patients, and the broader healthcare ecosystem.

As the leader of the Ocaliva Core Medical Team, the Executive Medical Director will lead a team of medical directors and collaborate closely with cross-functional partners to put patients at the center of every decision. This leader will help elevate medical strategic planning across all critical processes within and outside Medical Affairs, reshape how company success is measured, and elevate the scientific and ethical standards of Medical Affairs.

JOB RESPONSIBILITIES:

• Develop and execute the overarching medical strategy for Ocaliva, aligned with corporate and clinical goals; lead strategic planning across disease area education, clinical differentiation, and medical value articulation
• Manage, mentor, and grow a high-performing team of medical directors and scientific leaders
• Foster a culture of accountability, innovation, and purpose
• Lead data generation strategies including real-world evidence, observational studies, registries, and investigator-initiated trials. Ensure alignment with evidence gaps, regulatory trends, and payer needs
• Oversee the scientific communication platform, publication strategy, and congress planning to ensure consistent, credible, and high-impact dissemination of data
• Partner with MSL team lead to design and optimize the MSL strategy, insights generation, engagement planning, and performance metrics
• Work closely with Clinical Development, Regulatory Affairs, Commercial, Market Access, and HEOR to ensure integrated strategic planning
• Leverage principles of implementation science to translate evidence into practice and bridge the gap between clinical efficacy and real-world effectiveness
• Champion approaches that center patient experience and outcomes in every strategic decision; collaborate with Advocacy Director to build strategic partnerships with patient advocacy groups, with the goal of increasing disease education, awareness, and community engagement
• Monitor and interpret emerging scientific data and key publications within the therapeutic landscape to inform strategic decision-making and ensure the medical strategy remains current and differentiated
• Establish and sustain strong, strategic relationships with external thought leaders, medical influencers, and advocacy partners (including both professional societies and patient organizations) to enhance scientific exchange, build credibility, and align on shared goals in disease awareness and education
• Contribute to the development and execution of lifecycle management strategies for Intercept’s commercialized assets, ensuring Medical Affairs initiatives are fully integrated across Clinical, Regulatory, and Commercial teams to support the product's continued success and patient impact

Requirements

QUALIFICATIONS:

• Advanced medical sciences degree (MD, DO, PharmD, PhD) required with a minimum of 10 years of progressive industry experience in Medical Affairs, including roles with strategic accountability
• MD or DO degree preferred
• MPH degree in chronic disease epidemiology/biostatistics in addition to any of the above degrees will be a strong plus
• Prior experience in hepatology, gastroenterology, immunology preferred
• Proven ability to develop and execute medicalstrategies across the lifecycle of a product
• Deep understanding of scientific exchange, data generation, field medical execution, and publications planning
• Launch experience strongly preferred

REQUIRED KNOWLEDGE AND ABILITIES:

• Ability to travel up to 35% required, which may include overnight and/or weekend travel
• Strong understanding of drug development and commercialization process
• Must have knowledge of and be willing to comply with all regulatory/compliance policies consistent with position
• Ability to successfully manage a geographically diverse team
• Ability to work independently in a proactive manner
• Proficient in Microsoft Project, Excel, PowerPoint & Word
• Strong verbal and written communications skills
• Learning agility and ‘scalability’ to take on increasing responsibility as I