Postdoctoral Fellow - MICRO Tse Lab

Department:

SOM KC Department of Microbiology, Molecular Genetic and Immunology

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Tse Lab

Position Title:

Postdoctoral Fellow - MICRO Tse Lab

Job Family Group:

Professional Staff

Job Description Summary:

A postdoctoral position is available in the laboratory of Dr. Hubert Tse in the Department of Microbiology, Molecular Genetics, and Immunology at the University of Kansas Medical Center. Our research program seeks to increase our understanding of the immunological and molecular mechanisms involved in autoimmune dysregulation in Type 1 diabetes (T1D). Through the use of novel murine models of T1D, human translational studies, and innovative technologies including spatial transcriptomics, single cell RNA-sequencing, and induced-pluripotent stem cells, we are interested in determining how reactive oxygen species (ROS) synthesis contributes to innate immune responses and autoreactive T cell effector mechanisms involved in pancreatic ß-cell destruction. Additional research projects in the lab include the use of novel immunoprotection strategies to delay islet transplantation rejection and to define the role of insulin-producing ß-cells in T1D. We seek a motivated, creative, independent, and energetic applicant with excellent communication skills and organization. The laboratory uses immunological methods, molecular biology, cellular biochemistry, redox biology, murine models, imaging, and flow cytometry to discover and evaluate new mechanisms of autoimmune dysregulation. If interested, please send a letter describing your research experience/interest/future career aspirations, your CV, and contact information for three references.

Job Description:

Key Roles and Responsibilities:

Research Overview: Work with PI/faculty mentor, to design and perform research in induced-pluripotent stem cell-derived macrophages to examine their ability to delay autoimmune responses. Perform islet transplantation studies in mouse models of T1D to define optimal transplant sites and the use of accessory cells/therapies to prolong islet engraftment/protection. Determine how antiviral responses trigger T1D and define genetic mechanisms involved in disease susceptibility.

• Perform spatial transcriptomics to increase our understanding of the role of ß-cells in Type 1 diabetes.

• Perform data analysis, prepare data for presentations (oral and written), write manuscripts and other research documents.

Postdoc Expectations: The Postdoc will be expected to complete research projects under the guidance of the faculty mentor, record and interpret the results of their experiments in an (electronic) laboratory notebook, prepare publication-quality manuscripts (including figures and tables) and publish in peer-reviewed literature.

• Read literature articles, develop new ideas, and assimilate the information into his/her project design/interpretation.

• Dissemination of studies: Interact on a regular basis with their faculty mentor and members of the laboratory to discuss experimental design and interpretation of results.

• Present research aims and findings at department seminars and at scientific meetings. Write and publish their results as first author in abstracts, manuscripts, and posters.

• Submit fellowship applications, as eligible, to bolster research funding and CV building for projects.

Compliance: Attend and maintain compliance on all orientation and training sessions designated by the University and the Department of Microbiology, understand and follow all assigned duties, and attend regularly scheduled research team meetings.

Required Qualifications:

Education:

• PhD in Microbiology, Immunology, Biochemistry, Molecular Biology, or related field

Experience:

• Four (4) years of related research experience.

This job description is not designed to cover or contain a comprehensive listing of activities, duties or responsibilities that are required of the employee for this job. It is only a summary of the typical functions of the job, not an exhaustive list of all possible job responsibilities, tasks, duties, and assignments. Furthermore, job duties, responsibilities and activities may change at any time with or without notice.

Required Documents:

• Resume/CV

• Cover Letter

Comprehensive Benefits Package:

Coverage begins on