Senior Software Engineer (Full-stack), Science

The Chan Zuckerberg Initiative was founded by Priscilla Chan and Mark Zuckerberg in 2015 to help solve some of society’s toughest challenges — from eradicating disease and improving education to addressing the needs of our local communities. Our mission is to build a more inclusive, just, and healthy future for everyone.

The Team

CZI and its Biohub Network supports the science and technology that will make it possible to help scientists cure, prevent, or manage all diseases by the end of this century. While this may seem like an audacious goal, in the last 100 years, biomedical science has made tremendous strides in understanding biological systems, advancing human health, and treating disease. 

Achieving our mission will only be possible if scientists are able to better understand human biology. To that end, we have identified four grand challenges that will unlock the mysteries of the cell and how cells interact within systems — paving the way for new discoveries that will change medicine in the decades that follow:

• Building an AI-based virtual cell model to predict and understand cellular behavior
• Developing novel imaging technologies to map, measure and model complex biological systems  
• Creating new tools for sensing and directly measuring inflammation within tissues in real time.tissues to better understand inflammation, a key driver of many diseases
• Harnessing the immune system for early detection, prevention, and treatment of disease

Our work in science is focused on doing fundamental research to better understand human biology and building the tools and technology that move science forward to prevent disease and get to cures faster.. Join us in accelerating science.

The Opportunity

Join a dynamic team within CZI’s Science Initiative focused on building user-facing applications that empower researchers through scalable, flexible, and intelligent workflows. This team plays a key role in accelerating scientific discovery by developing generalized tools that integrate machine learning services, human-in-the-loop capabilities, and customizable data processing.

Our mission is to unify the diverse functionalities and resources available across the broader organization — from data services to inference pipelines — into a cohesive platform that supports both internal collaborators and the broader scientific community. Whether users are bringing their own datasets, leveraging CZI tools, or customizing their processing pipelines, this role offers the chance to shape how cutting-edge science is conducted.

What You'll Do

• Design, develop, and maintain scalable full-stack web applications that power research workflows across scientific domains.
• Collaborate closely with scientists, product managers, and other engineers to build intuitive, flexible user interfaces and backend services.
• Integrate diverse services and tools — including ML inference pipelines, human-in-the-loop interfaces, and data management systems — into a cohesive platform.
• Ensure high standards of code quality, performance, and maintainability through code reviews, testing, and automation.
• Drive architectural decisions and contribute to long-term technical planning to support extensibility and scale.
• Build systems that enable researchers to bring their own data, customize processing, and adapt workflows to their unique needs.
• Partner with infrastructure and platform teams to ensure seamless deployment, observability, and operational stability of services.

What You'll Bring

• 7+ years of professional experience developing full-stack web applications with modern front-end frameworks (e.g., React) and backend technologies (e.g., Node.js, Python).
• Proven ability to design and implement scalable APIs and data-driven applications.
• Expert knowledge of computer science, with strong competencies in data structures, algorithms, and software design.
• Familiarity with infrastructure concepts such as containerization (Docker), orchestration (Kubernetes), and CI/CD practices.
• Experience integrating or building around AI/ML services, especially in application layers involving inference or interactive AI tools.
• Strong collaboration skills with a history of working cross-functionally with technical and non-technical stakeholders.
• A product mindset with attention to user experience, performance, and extensibility.
• Curiosity, flexibility, and a desire to work in a mission-driven, rapidly evolving environment.

Compensation

The Redwood City, CA base pay range for a new hire in this role is 190,000 - $261,800. New hires are typically hired int