(Sr.) Research Associate, In Vivo Pharmacology

Company Summary:

Ampersand Biomedicines is an innovative, privately held biotechnology company leading the way in developing multi-specific medicines that specifically target complex biological systems. With a strong emphasis on innovation, Ampersand cultivates a highly dynamic and entrepreneurial environment. We are actively seeking an exceptional in vivo pharmacologist to join our team and make significant contributions to our pioneering work.

Ampersand was founded in Flagship’s venture creation engine, where companies such as Moderna Therapeutics (NASDAQ: MRNA) and Seres Therapeutics (NASDAQ: MCRB) were conceived and created. Since Flagship’s founding in 2000, the firm has originated and fostered the development of more than 100 scientific ventures resulting in over $34 billion in aggregate value, more than 500 issued patents and more than 50 clinical trials for novel therapeutic agents.

Position Summary:

Ampersand is seeking a highly motivated and enthusiastic associate to join our in vivo pharmacology team and contribute to our in vivo studies involving antibodies and related biological molecules. This is an exciting opportunity to be part of the development of the next generation of biologics within a dynamic and entrepreneurial environment. The position is based in our lab located in the Boston area and requires in-person presence.

As a member of our team, the individual will play a key role in studying the in vivo pharmacology of antibodies and related molecules. Their primary responsibility will involve supporting mouse studies to investigate the pharmacokinetics and biodistribution of candidate molecules. Working closely with Ph.D. scientists, they will assist in dosing, animal monitoring, and sample collection. They will also take ownership of sample processing and conduct assays such as real time PCR, ELISA, flow cytometry, and IHC.

Joining our team provides an opportunity to contribute to cutting-edge research and work alongside experienced scientists in a collaborative environment. We are excited to welcome a dedicated individual who is eager to make a significant impact in the field of biologics drug development.

 

Key Responsibilities

• Administration of antibodies and related molecules to mice by diverse routes of delivery.
• Collecting blood and tissue samples to conduct pharmacokinetic and biodistribution studies.
• Assisting in surgical procedures, including dissections and collection of organs.
• Monitoring animals and actively contributing to the implementation of in vivo disease models.
• Providing support for ex vivo studies to characterize the efficacy of antibodies and other molecules following in vivo experiments.
• Analyzing data and communicating results effectively to the team.
• Maintaining accurate and thorough written records of laboratory procedures, results, and conclusions.

Required Qualifications and Capabilities

• Bachelor’s or Master’s degree in biology, pharmacology, or a related field.
• Minimum of 3 years post-degree experience in mouse handling, with preference given to candidates with industry experience.
• Proficiency in animal handling procedures, including dosing via intraperitoneal (IP), subcutaneous (SC), and intravenous (IV) routes.
• Experience in blood collection (saphenous vein, cardiac blood collection), anesthesia administration, surgical procedures, dissection techniques, and tissue collection.
• Familiarity with imaging technologies like IVIS for animal or organ imaging.
• Strong written and verbal communication skills to effectively convey scientific data and results.
• Highly motivated and a strong team player, thriving in a fast-paced, inclusive, team-oriented, and multidisciplinary environment typically found in small biotech companies.
• Familiarity with molecular biology techniques, including real-time PCR, RNA, and protein preparation.
• Knowledge and familiarity with various assays, including ELISA and cellular phenotyping through flow cytometry.

 

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