Senior Scientist, Chemical Biotechnologies - Protein Engineering

Job Description

The Chemical Biotechnologies group within the Process Research & Development Enabling Technologies Department in Rahway, New Jersey is seeking a Senior Scientist to expand our capabilities to design and engineer proteins with novel functions. The mission of the group is to invent, develop, and implement biomolecules and biocatalytic processes to advance our Company’s pipeline and our impact on the scientific community. We view protein engineering as a key enabler in modern drug discovery and development, and are committed to developing novel methodologies and technologies that enhance protein engineering to improve human health. We leverage computational protein design, advanced automation, high-throughput screening, and machine learning to accelerate the development of novel proteins to produce therapeutics to support both clinical and commercial manufacturing. The candidate will work closely with a diverse and collaborative group of chemists, biologists, computer scientists, and engineers. The group collaborates broadly within our Company, with academic leaders, and with industry partners to expand and accelerate the impact of protein engineering on human health.

Job Responsibilities:

In this role, the candidate will directly contribute to the invention of novel proteins by guiding gene acquisition, designing and building high-quality DNA libraries, expressing large protein libraries, developing assays, and/or characterizing libraries using high-throughput screens and selections. They will leverage skills in bioinformatics, molecular biology, and/or biochemistry to advance hypothesis driven protein engineering programs. They will develop engineering strategies, choose which engineered proteins to select as leads, and deliver biocatalysts and/or biotherapeutics with improved functions and properties. As part of cross-functional teams, they will collaborate across groups to solve complex problems and develop novel protein engineering technologies that enable drug discovery, development, and commercialization.  They will attend scientific conferences, contribute to publications, and help to set the strategy of the group.  The successful candidate will join a diverse group of innovative scientists that are driving the next revolution in bioengineering. 

Education:

• B.S. degree with 5+ years of experience or M.S. degree with 4+ years of experience in Molecular Biology, Synthetic Biology, Bioengineering, Biochemistry or related field.

Or

• PhD degree in Molecular Biology, Synthetic Biology, Bioengineering, Biochemistry, or a related field (with expected completion no later than October 2025).

Requirements:

• Broad experience and knowledge in synthetic biology, biological engineering, protein design and/or directed evolution.

• Significant expertise in one of the following: molecular biology, biochemistry, biophysics, computational protein design, or metabolic engineering.

• Demonstrated ability to work in a collaborative multi-disciplinary team environment.

• Excellent communication and organizational skills.

• Strong problem-solving and troubleshooting abilities.

Preferred Experience and Skills:

• Experience engineering one of the following: novel biocatalysts, biosynthetic pathways, amino acid/peptide modifying enzymes, protein assemblies, and/or de novo proteins.

• Experience with multiple strategies to create genetic diversity, multiple host organisms and/or cell free expression systems, and/or multiple high-throughput screening/selection methods.

• Familiarity with one or more of the following areas are highly desired: next-generation sequencing, computational protein design, machine learning, microfluidics, and/or automation.

• Experience with Python, C++, or R

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