Senior Scientist/Principal Scientist, In vivo Pharmacology, Discovery Technologies

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.

Actual compensation will depend on a candidate’s education, experience, skills, and geographic location.  The anticipated wage for this position is

$69,000 - $179,300

Overview:

At Lilly, we serve an extraordinary purpose. We make a difference for people around the globe by discovering, developing and delivering medicines that help them live longer, healthier, more active lives. Not only do we deliver breakthrough medications, but you also can count on us to develop creative solutions to support communities through philanthropy and volunteerism.

 

Position Summary:

The Senior Scientist/Principal Scientist in the Discovery Technologies In vivo Pharmacology group will be part of a dynamic group of scientists conducting various research projects to identify large molecule/biologics which can effectively treat various forms of cancer. The candidate will collaborate with discovery teams in NYC, Indianapolis, San Francisco and Louisville for design and execution of studies. The In vivo pharmacology scientist will design and execute experiments and will also be responsible for performing or collaborating in vivo efficacy and PK/PD studies done in preclinical models. Oversight and/or contribution to ADME work during drug development may be required. The in vivo pharmacology scientist will report findings directly to both the oncology scientific and executive leadership and will be a key member of the discovery organization being responsible for maintaining the scientific quality and efficiency of the organization, as well as assist and guide the strategic direction of the company. The candidate is expected to be a dynamic and motivated scientist who can drive experiments and research activities independently, while collaborating extensively with the entire organization to execute various research programs.

 

 

Responsibilities:

·         Design, execute in vivo studies with pre-clinical discovery and translational biology teams

·         Interact and collaborate with various discovery technologies functional teams to develop and implement novel in vivo models

·         Prepare drug solutions and inoculations, multiple routes of drug administration (e.g. subcutaneous, tail vein, intraperitoneal, and retro-orbital injection and oral gavage), animal health monitoring, anesthesia, blood samplings, , xenografts, syngeneic mouse models, humanized mouse models

·         Perform cardiac, retro-orbital, and facial bleeds, and tumor injections

·         Perform tumor measurements using calipers

·         Harvest blood, tumor and tissue samples from animals to help establish PK/PD and toxicity measurements, flow cytometry analysis and histology.

·         Culture tumor cells according to SOPs and contribute to the development of SOPs

·         Stay current on cutting edge technologies and work collaboratively with the in vivo team to validate and implement new in vivo model systems

·         Provide scientific expertise on practical implementation of various in vivo applications to support projects across the entire oncology organization

·         Work with the entire in vivo team to ensure all instrumentation is properly maintained and calibrated

·         Provide scientific expertise when determining organizations to strategically partner with

·         Proper documentation and archiving of data and analyses

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