Senior Scientist, Lead Discovery Chemistry Encoded Technologies

GSK is a world leading research-based pharmaceutical company that combines both individual talent & technical resources to create a platform for the delivery of strong growth in a rapidly changing healthcare market.  Our mission is to improve the quality of human life by enabling people to do more, feel better, & live longer. GSK is headquartered in London, UK with operations in the US; this opening is located at the Cambridge, MA, USA site working 5 days per week onsite with some work from home flexibility.

GSK is seeking a medicinal chemist to join the Encoded Technologies (ET) group. ET is a multidisciplinary group dedicated to the discovery of small molecule hits and the development of lead series. As a Senior Scientist, Lead Discovery Chemistry Encoded Technologies you will identify potential hits from our world leading DNA-encoded library (DEL) platform, synthesize potential hits off-DNA to confirm their activity, and optimize small molecules around drug-like properties (potency, selectivity, solubility, permeability, etc.). You will also work side-by-side with DEL library chemists, biophysicists, computational informaticists, and biologists to push the boundaries of DEL capabilities so that we can better fill the GSK pipeline with high quality chemical assets.

Key Responsibilities:

This role will provide YOU the opportunity to lead key activities to progress YOUR career, these responsibilities include some of the following.

• Design and synthesize compounds off-DNA for hit confirmation

• Conduct parallel synthesis in an array format

• Analyze, interpret, and report experimental results in ET Chemistry team meetings

• Maintain detailed records of experiments in electronic lab notebooks in accordance with company policy

• Share in responsibilities to support general lab functions

• Contribute to the writing and conceptual framework of publications, presentations, and patents

• Establish and maintain knowledge of literature related to areas of research

Why you?

Basic Qualifications:

We are looking for professionals with these required skills to achieve our goals:

• BS degree with 3 or more years of relevant work experience, or MS in Chemistry

• Experience training in synthetic organic chemistry methods

• Experience with analytical tools including LCMS and NMR

• Experience with analytical and preparative purification methods (HPLC, silica gel chromatography, TLC, etc)

• Experience writing and conceptual framework of publications, presentations, and patents

Preferred Qualifications:

If you have the following characteristics, it would be a plus:

• Synthetic organic chemistry research experience in an industrial environment

• Experience with multistep organic synthesis

• Ability to work independently to design experiments and analyze and present data

• Ability to work effectively in a collaborative, multidisciplinary matrix environment

• Highly organized with strong attention to detail and a focus on quality results

• Excellent oral and written communication skills

#LI-GSK

Please visit  GSK US Benefits Summary to learn more about the comprehensive benefits program GSK offers US employees.

Why GSK?

Uniting science, technology and talent to get ahead of disease together.

GSK is a global biopharma company with a special purpose – to unite science, technology and talent to get ahead of disease together – so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns – as an organisation where people can thrive. We prevent and treat disease with vaccines, specialty and general medicines. We focus on the science of the immune system and the use of new platform and data technologies, investing in four core therapeutic areas (infectious diseases, HIV, respiratory/ immunology and oncology).

Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders, it’s also about making GSK a place where people can thrive. We want GSK to be a place where people feel inspired, encouraged and challenged to be the best they can be. A place where they can be themselves – feeling welcome, valued, and included. Where they can keep growing and look after their wellbeing. So, if you share our ambition, join us at this exciting moment in our journey to get Ahead Together.

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