Pharmacokinetics & Drug Metabolism: Senior Scientist – Mass Spectrometry and Metabolomics

Career Category

Job Description

Join Amgen’s Mission of Serving Patients

At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do.

Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.

Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

Pharmacokinetics & Drug Metabolism – Mass Spectrometry and Metabolomics - Senior Scientist

What you will do

Let’s do this. Let’s change the world. In this vital role you will be a part of the department of pharmacokinetics and drug metabolism (PKDM) within Amgen Research. This group is dedicated to the discovery and development of novel, effective, and safe medicines.

The Sr. Scientist will also implement bioanalytical methods for the quantitative and qualitative analysis of various molecular modalities (antibody-drug conjugates, small molecules, lipids, oligonucleotides, peptides, proteins, etc.) in plasma, tissues, and other biological matrices in support of the development of Amgen’s innovative pipeline.

This role requires an excellent understanding of state-of-the-art bioanalytical techniques and an individual that can work collaboratively in a fast-paced flexible work environment. This position is primarily lab-based, necessitating most of the work to be conducted on site.

Responsibilities

• Develop targeted and un-targeted metabolomics and lipidomics approaches to support biomarker discovery and mechanism of action investigations.

• Employ bioinformatics analysis of complex datasets to interpret and visualize data and effectively communicate results to cross-functional teams.

• Develop and perform quantitative LCMS assays for various molecular modalities.

• Be able to troubleshoot independently when instrument or assay problems arise.

• Other responsibilities will include basic biochemistry research, electronic laboratory notebook keeping and communication of results to project teams.

What we expect of you

We are all different, yet we all use our unique contributions to serve patients. The dynamic professional we seek is a scientist with these qualifications.

Basic Qualifications:

• Doctorate degree in Biochemistry, Analytical Chemistry, or a related discipline with a background in metabolomics and/or lipidomics research OR

• Master’s degree and 3 years of the relevant experience OR

• Bachelor’s degree and 5 years of the relevant experience

Preferred Qualifications:

• Demonstrated track record of successfully developing or implementing LCMS methods for metabolomics and lipidomics is strongly preferred.

• Experience conducting metabolic flux analysis using stable isotope tracing to probe metabolic pathway activity is desirable.

• Fluency in Python and/or R, as well as the relevant techniques required for statistical analysis, data processing and visualization.

• Hands on experience in sample preparation (biological processing, tissue homogenization, immunoaffinity capture, enzymatic digestion, SPE etc.) and experience with automated platforms (AssayMAP Bravo, Tecan etc.).

• Hands on experience in various HPLC, CE, and Mass Spec instruments is preferred, such as high-flow LC, micro-flow LC, nanoflow LC, QQQ, ToF, Orbitrap, etc.

What you can expect from us

As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we’ll support your journey every step of the way.

The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.

In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for s