Associate Scientist/Scientist

About Eidos Therapeutics & BridgeBio Pharma

Eidos Therapeutics, an affiliate of BridgeBio Pharma, is a commercial stage biopharmaceutical company focused on addressing the large and growing unmet need in diseases caused by transthyretin, or TTR, amyloidosis, or ATTR. We seek to treat this well-defined family of diseases at their collective source by stabilizing TTR. Attruby (acoramdis) is an orally administered small molecule designed to stabilize TTR, a best-in-class treatment aiming to halt the progression of ATTR diseases.

BridgeBio is a biopharmaceutical company founded to discover, create, test, and deliver transformative medicines to treat patients who suffer from genetic diseases and cancers with clear genetic drivers. We bridge the gap between remarkable advancements in genetic science in academic institutions and the delivery of meaningful medicines to patients. Founded in 2015, the company has built a portfolio of 30+ drug development programs ranging from preclinical to late-stage development in multiple therapeutic areas including genetic dermatology, precision oncology, cardiology, endocrinology, neurology, pulmonology, and renal disease, with two approved drugs. 

Our focus on scientific excellence and rapid execution aims to translate today’s discoveries into tomorrow’s medicines. We have U.S. offices in San Francisco, Palo Alto, and Raleigh, with small satellites in other parts of the country. We also have international offices in Montreal, Canada, and Zurich, Switzerland, and are expanding across Europe. 

To learn more about our story and company culture, visit us at eidostx.com/ | https://bridgebio.com

Who You Are

We are looking for a highly motivated and innovative scientist to join our biologics discovery group at BridgeBio. The selected candidate will work within a fast-paced, interactive, and innovative research team to assist in the development of novel antibodies. This role will require a highly cross-functional skillset, including immunology and protein engineering.

Responsibilities

• Conduct binding assays (e.g., ELISA, flow cytometry, SPR,BLI) to characterize antibody-antigen interactions
• Express, purify, and characterize proteins and antibodies with techniques including ExpiCHO/Expi293 transfection, purification using Protein A, IMAC Ni-NTA etc., analysis using SEC, SDS Page, Western blot, BLI/SPR etc.
• Use reporter assays and primary cells to functionally characterize antibody candidates 
• Analyze experimental data and present findings to the team
• Maintain accurate and detailed laboratory records, including experimental procedures, results, and conclusions
• Contribute to the preparation of technical reports, presentations, and scientific publications
• Participate in project meetings and contribute to the design and planning of experiments
• Communicate effectively with team members and external collaborators

No matter your role at BridgeBio, successful team members are:

• Patient Champions, who put patients first and uphold strict ethical standards
• Entrepreneurial Operators, who drive toward practical solutions and have an ownership mindset
• Truth Seekers, who are detailed, rational, and humble problem solvers
• Individuals Who Inspire Excellence in themselves and those around them
• High-quality executors, who execute against goals and milestones with quality, precision, and speed

Education, Experience & Skills Requirements

• Bachelor’s (4+ years experience) or Masters’ degree (2+ years experience) in Molecular Biology, Biochemistry, Immunology or related area is required
• Knowledge, Skills, and Abilities
  • Proficiency in molecular biology techniques (e.g., cloning, PCR, Gibson assembly, Golden Gate)
  • Experience with antibody screening and characterization assays (e.g., ELISA, flow cytometry, SPR, BLI)
  • Experience with downstream immunological assays (eg ADPC, ADCC, CDC, multicolor flow cytometry)
• Familiarity with protein expression and purification methods (e.g., mammalian, insect, and bacterial expression systems)
• Ability to handle multiple projects simultaneously
• Ability to work independently and as part of a team
• Must be comfortable with ambiguity
• Fast (extremely fast) learner
• Strong communication skills

What We Offer

• Patient Days, where we are fortunate to hear