Sr Manager, Business Architecture CAR-T

At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at https://www.jnj.com

Job Function:

Supply Chain Manufacturing

Job Sub Function:

Manufacturing Process Improvement

Job Category:

Professional

All Job Posting Locations:

Horsham, Pennsylvania, United States of America, Malvern, Pennsylvania, United States of America, Spring House, Pennsylvania, United States of America, Titusville, New Jersey, United States of America

Job Description:

About Innovative Medicine

Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow.

Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way.

Learn more at https://www.jnj.com/innovative-medicine

We are searching for the best talent for a Sr Manager, Business Architecture to join our Team. This is an onsite/hybrid position.

Are you interested in joining a team that is positively impacting patients' lives by ensuring high quality and reliable supply of our cell therapy products? Apply today for this exciting opportunity to be part of the #CAR-T team!

The Senior Manager, Business Architecture is responsible for define how the organizations people, processes, information and technology work together to deliver cell therapy products with the best cost, quality and turnaround time to meet patient needs. They will collaborate with representatives across clinical, technical, supply chain, and quality functions to identify needs and align on a future state business model which they will deliver.

Key Responsibilities:

• Lead business architecture strategy development and implementation for CAR-T therapies

• Establish cross-functional governance frameworks to align on performance objectives, resolve systemic challenges, and prioritize strategic investments

• Influence leadership across Commercial, Technical Operations, Quality, and IT, integrating business priorities into scalable process and system designs

• Lead all aspects of end-to-end traceability between enterprise systems, SOPs, work instructions, and business processes, ensuring clarity, compliance, and consistency.

• Define and evolve indicators and performance metrics in collaboration with Commercial and Operations leadership to monitor business performance, customer experience, and system health at both the operational and executive levels.

• Deliver a refined, end-to-end CAR-T process map that integrates clinical workflows, technology touchpoints, Engineering DPFDs and compliance requirements and provides input into an IT Execution Plan.

• Establish standardized process documentation architecture, including SOP linkage, work instructions, systems, and change control alignment across platforms.

• Develop and implement a governance model for process ownership, change prioritization, and experience-led process improvement.

Qualifications:

Education:

• Bachelor’s degree in Engineering, Business, Operations, or related field.

Experience and Skills:

Required

• Minimum eight (8) years of experience in process design, operational excellence, or end-to-end business process management within complex, highly regulated environments (e.g., Biopharma, MedTech, supply chain).

• Proven success leading cross-functional process development and governance efforts.

• Demonstrated ability to translate business strategy into operational models, indicators, and system requirements that support scale, compliance, and customer experience.

• Strong understanding of systems architecture, digital tools, and interfaces (e.g., MES, LIMS, ERP, customer portals), and how they intersect with business process execution.

• Comfortable operating in ambiguous, constantly evol