Senior Scientist

Working with Us
Challenging. Meaningful. Life-changing. Those aren’t words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You’ll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams rich in diversity. Take your career farther than you thought possible.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: careers.bms.com/working-with-us.

The Oncology Thematic Research Center at BMS is one of the fundamental research and early development engines delivering oncology therapeutics to patients.  The scientists at this state-of-the-art research and development site in Cambridge focus on novel tumor intrinsic targets and pathways for tumors that are refractory to current Immuno-Oncology and Oncology therapies, and implement our discovery platforms across all of our therapeutic areas of focus.  We are a fully integrated drug discovery through translational and early clinical development organization which exploits state-of-the-art in vitro, in vivo and ex-vivo models of cancer biology to identify and validate targets.   We partner closely with colleagues in Translational Medicine, Informatics and Predictive Sciences and Early Clinical Development to generate biomarker and patient enrichment hypotheses to enable efficient decision making in early clinical trials. We are optimally positioned to complement the world-class translational expertise, biology and leading academic research centers in the area.

The new Bristol Myers Squibb research site in Cambridge Crossing will help us continue to deliver on our mission, positioning the company and our scientists in the heart of a vibrant ecosystem of world-class science, innovation, and business opportunities.

Position Summary:

We are seeking a highly motivated, experienced and talented Sr. Scientist to join our Oncology Research and Development team. This individual will play a key role in advancing our oncology drug discovery programs, with a focus on target identification, validation and mechanism of action studies. This position is heavily focused on wet lab work, contributing to cutting-edge research projects aimed at understanding cancer biology, identifying novel drug targets, and developing new therapeutic approaches. The successful candidate will bring deep scientific expertise, creative problem-solving skills and a collaborative mindset to drive impactful research.   

Position Responsibilities:

In the role as a Sr. Scientist within the Discovery Biosciences team, the ideal candidate will:

• Conduct full time laboratory-based research supporting target identification, oncology drug discovery and development.

• Execute a variety of molecular and cell biology, and biochemical assays including:

  • Maintenance and manipulation of 2D and 3D cell cultures, including spheroids and organoids.

  • Lentiviral and nucleofection based gene transfer and genome editing.

  • Target gene perturbation using CRISPR/Cas9, shRNA and siRNA.

  • Cell viability and cytotoxicity assays

  • Large scale functional genetic and phenotypic screens.

  • RT-QPCR and western blot, sample prepping for RNA-seq. 

  • co-immunoprecipitation (coIP), and other protein interaction studies.

  • ELISA, Meso Scale Discovery (MSD), and other immunoassays.

• Design, optimize, and troubleshoot complex cell-based assays to evaluate therapeutic candidates and understand cancer signaling pathways.

• Collaborate with cross-functional teams, including medicinal chemistry, bioinformatics, and in vivo pharmacology, to advance project goals.

• Analyze and interpret experimental data, maintain accurate and detailed lab records, and present findings in team meetings.

• Contribute to the preparation of technical reports, publications, and presentations.

Experience =

Basic Qualifications:

• Bachelor’s Degree

  • 7+ years of