Senior Specialist, Chemistry (Onsite)

Job Description

The Process Chemistry group within the Small Molecule Process Research & Development Department in Rahway, New Jersey is seeking a Senior Specialist to play a key role in advancing our pipeline of drug substances, including small molecules, macrocyclic peptides, and bioconjugates. This lab-based position offers an opportunity to drive Process Characterization of late-stage programs through establishment of proven acceptable ranges, fate and purge studies, and chemical marker preparation.  This individual will also synthesize starting materials and intermediates to support route scouting efforts and support kilo lab scale syntheses.  The ideal candidate is highly motivated and has substantial synthetic chemistry experience, can perform independent analysis using various analytical characterization methods, and pays close attention to detail to ensure safe lab practices and rigorous documentation of work. A proven record of technical strength, clear written and oral communication, and collaboration and adaptability in a fast-paced, dynamic research environment is essential. 

 

Specific Responsibilities 

• Laboratory-based characterization of late-stage syntheses to support commercialization of small molecule manufacturing by performing Design of Experiments, fate and purge studies, and chemical marker preparation

• Laboratory work with a large variety of chemicals, using a set of modern manual and automated laboratory equipment, and leveraging an array of analytical technologies, in a safe, compliant, and rigorously documented manner

• Laboratory-based synthesis and characterization of starting materials and intermediates to support route scouting, including kilo lab scale up of intermediates and APIs

• Non-lab-based work includes experimental planning, data analysis, and writing clear and concise development reports

Education 

Minimum Requirement 

• Ph.D. degree in Chemistry, an M.S. degree with 6 years of pharma/biopharma experience, or a B.S. with 9 years of pharma/biopharma experience.

Required Experience and Skills 

• Training must be in the field of organic synthesis, including synthetic methodology, catalysis, or total synthesis
• Significant experience in chemical synthesis, compound purification, and analytical characterization, including HPLC, MS, and NMR techniques
• Strong written and oral communication skills and the ability to work effectively and with urgency in a collaborative and team environment
• The ability to work independently with minimum supervision of daily tasks
• Productivity and efficiency working in an organic chemistry lab

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Required Skills:

Biopharmaceutical Industry, Biopharmaceuticals, Biopharmaceutics, Chemical Synthesis, Cross-Cultural Teams, Data Analysis, Deviation Management, Facility Management, Good Manufacturing Practices (GMP), Nuclear Magnetic Resonance Spectroscopy (NMR), Pharmaceutical Biology, Pharmacokinetics, Proton Nuclear Magnetic Resonance, Sterile Manufacturing, Vaccine Manufacturing

Preferred Skills:

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