Senior Scientist, Functional Genomics

Job Title: Senior Scientist, Functional Genomics

Location: Cambridge, MA

About the Job

Are you ready to shape the future of medicine? The race is on to speed up drug discovery and development to find answers for patients and their families. Your skills could be critical in helping our teams accelerate progress. 

We are seeking a highly motivated and creative scientist to join the Functional Genomics cluster within the Target, Disease, and Systems Biology function in Sanofi Research. They will drive the application of functional genomics target ID and validation to advanced disease models in order to elucidate disease mechanisms and discover novel targets across immunology, ophthalmology, neurology, oncology, and rare disease. The successful candidate will collaborate closely with therapeutic area colleagues to advance functional genomics target discovery and validation and develop new screening workflows in advanced disease models including primary cells, iPSC-derived cells, and co-culture/organoid systems. This is a unique opportunity to work at the intersection of functional genomics, in vitro modelling, and disease biology to advance therapeutic target discovery.

We are an innovative global healthcare company with one purpose: to chase the miracles of science to improve people’s lives. We’re also a company where you can flourish and grow your career, with countless opportunities to explore, make connections with people, and stretch the limits of what you thought was possible. Ready to get started?

Main Responsibilities:

• Independently perform experiments, including pooled and arrayed CRISPR screens, in human cellular disease models to validate targets and understand mechanism of action.

• Develop cellular and molecular assays to study disease processes and validate targets in innovative disease models such as primary or iPSC-derived cells, co-culture systems, or organoids.

• Innovate in functional genomics technology by refining, scaling, or automating experimental methodologies to systematically explore gene function in disease contexts.

• Collaborate closely with therapeutic area experts to advance target discovery and in vitro disease modeling.

• Communicate your work through scientific publications, patent and regulatory filings, and presentations at internal and external meetings.

About You

• Ph.D. or equivalent experience in cell biology, molecular biology, genomics, or related field. Postdoctoral training and/or industry experience will be highly valued.

• Hands-on experience in CRISPR genome editing or screening and disease modeling, such as in primary or iPSC-derived cells, co-culture systems, or organoids, is key.

• Experience in target or drug discovery, especially in immunology, ophthalmology, or neurology, would be highly valued.

• Experience in high-throughput assay development, screening platforms and robotics, flow cytometry, imaging, and/or computational data analysis would also be valued.

• Excellent communication, organizational, and team skills with a track record of success working collaboratively across disciplines.

Why Choose Us?

• Bring the miracles of science to life alongside a supportive, future-focused team.

• Discover endless opportunities to grow your talent and drive your career, whether it’s through a promotion or lateral move, at home or internationally.

• Enjoy a thoughtful, well-crafted rewards package that recognizes your contribution and amplifies your impact.

• Take good care of yourself and your family, with a wide range of health and wellbeing benefits including high-quality healthcare, prevention and wellness programs and at least 14 weeks’ gender-neutral parental leave.

Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gend