Director, Delivery Chemistry

Company Description:

Evercrisp Biosciences, founded by world-renowned scientists with expertise in cutting-edge proprietary technologies, operates in stealth mode with substantial Series A backing from Apple Tree Partners (ATP). Evercrisp is focused on tackling genetically validated, “difficult-to-drug” targets, particularly in areas of high unmet need where genomic medicines can create transformative outcomes. At Evercrisp, innovation, collaboration, and a deep commitment to advancing human health drive our mission to develop first-in-class therapeutics.

Position Summary:

We are seeking a dynamic and innovative leader to serve as Director of Delivery Chemistry, spearheading the development of targeted drug conjugates. This role will focus on the design, synthesis, and characterization ofprotein-drug conjugates, leveraging Evercrisp’s novel drug delivery platform or rare genetic diseases to advance therapeutic programs from discovery to IND-enabling studies. The ideal candidate thrives in a fast-paced, collaborative environment and brings both technical expertise alongside strong leadership skills.

Key Responsibilities:

• Lead therapeutic programs from early discovery through IND-enabling studies, ensuring high-quality outcomes and strategic alignment with company goals.
• Design, synthesize and optimize innovative solutions for formulation and delivery challenges associated with complex macromolecular therapeutic modalities.
• Manage and mentor a high-performing team of scientists responsible for the synthesis and characterization of protein, polymer, oligonucleotide, and small molecule conjugates.
• Oversee data analysis, data interpretation, and decision-making to drive project success.
• Provide technical leadership to staff performing complex scientific challenges across drug discovery pipelines.
• Maintain detailed records in ELNs to ensure data integrity and accessibility for team collaboration
• Contribute to intellectual property development, including patents and high impact scientific publications.
• Collaborate cross-functionally with Protein Sciences, Cell Biology and In Vivo Biology to troubleshoot technical challenges and drive innovation.

Qualifications:

• Ph.D. in Chemistry, Biochemistry, or a related field with 6+ years of industry experience.
• Deep expertise in bioconjugation chemistry and the design of protein-drug conjugates.
• Proven experience leading functional teams in a fast-paced and rapidly evolving industry (2-5 direct reports).
• Hands-on experience with analytical techniques for protein-drug conjugates.
• Demonstrated leadership in drug discovery and development, including successful of IND filings.
• Prior experience in the development of therapeutic oligo delivery systems.

Skills & Attributes:

• Strong scientific communication skills, capable of distilling complex data for decision-making.
• Strong strategic thinking and problem-solving skills with the ability to drive innovation.
• Highly organized and detail-oriented, with a commitment to data integrity and safety best practices.
• Empathetic and inclusive leader who fosters team collaboration and professional development, and a culture of open feedback and trust.
• Ability to manage multiple projects in a dynamic environment while maintaining high-quality outcomes.

What We Offer:

At Evercrisp Biosciences, you’ll be part of a passionate team working at the forefront of genetic medicine. We offer a competitive compensation package, comprehensive benefits, and the opportunity to grow professionally in a highly innovative environment.

At Evercrisp, we value diversity, encourage professional growth, and provide competitive benefits and compensation. Evercrisp is an equal opportunity employer. We celebrate diversity and are committed to creating an inclusive environment for all employees.