Postdoctoral Associate Genetics-Therapeutic RNA Development

Description

We are seeking a highly motivated postdoctoral researcher to join our team focused on the development of therapeutic RNAs. Our lab is at the forefront of RNA biology, utilizing massively parallel reporters to identify sequence and structural elements that regulate mRNA stability and translation.

In this role, the candidate will leverage the Giraldez Lab's expertise in RNA biology, genomics, and computational biology to engineer novel therapeutic mRNAs. The position involves exploring innovative solutions for gene therapy and vaccine development using lipid nanoparticles (LNPs), advanced genomics tools, and massively parallel reporter assays to create tissue-specific mRNAs.

Publications List: https://pubmed.ncbi.nlm.nih.gov/?term=giraldez AJ&sort=date

 Key Responsibilities:

• Design and development of therapeutic RNA molecules for gene therapy applications.
• Conduct in vivo experiments using mouse models to evaluate the efficacy and safety of RNA-based therapies.
• Utilize massively parallel reporter assays to engineer tissue-specific mRNAs.
• Collaborate with experts in lipid nanoparticle formulation and delivery systems to optimize RNA targeting and delivery.
• Apply genomic technologies to analyze RNA expression, stability, and functional outcomes in various models.
• Perform tissue culture experiments and integrate genomic approaches to investigate RNA regulation and therapeutic outcomes.
• Interpret data, write manuscripts, and present findings at conferences and seminars.

Preferred Expertise:

• Experience with in vivo studies using mouse models, including handling, injections, and analysis of therapeutic outcomes.
• Strong background in lipid nanoparticles (LNPs) for RNA delivery and formulation.
• Expertise in genomics, including RNA sequencing, gene expression analysis, and bioinformatics.
• Experience in tissue culture and genomic approaches for investigating RNA stability and functionality.
• Familiarity with molecular biology techniques such as cloning, qPCR, and western blotting.
• Publications:  https://pubmed.ncbi.nlm.nih.gov/?term=giraldez AJ&sort=date

Qualifications

• PhD in molecular biology, RNA biology, genomics
• Proven track record of scientific publications in peer-reviewed journals.
• Ability to work both independently and as part of a collaborative team.
• Strong independence and drive, as well as analytical and problem-solving skills.

Application Instructions

Please upload:  your CV, a one-page cover letter, a one-page description of previous research, and the names and contact information of three references

Equal Employment Opportunity Statement

Yale University is an Affirmative Action/Equal Opportunity employer. Yale values diversity among its students, staff, and faculty and strongly welcomes applications from women, persons with disabilities, protected veterans, and underrepresented minorities.