Sr. Research Associate - AAV Manufacturing

The Company

Dyno Therapeutics is reshaping the gene therapy landscape through AI-powered vectors. Through the application of our transformative technologies and strategic partnerships with leaders in gene therapy, we believe a future with life changing gene therapies for millions of people is within reach. 

Our team includes world-class molecular and synthetic biologists, protein engineers and gene therapy scientists working alongside software engineers, data scientists, and machine learning experts to transform the landscape of available gene therapy capsids. Dyno was named Startup of the Year in 2020 by Xconomy, Endpoints 11 in 2021, and one of America’s Best Startups in 2022 & 2023 by Forbes!

The Role

Sr. Research Associate - AAV Manufacturing. Producing high-quality AAV capsids is essential for Dyno’s mission to advance gene therapy. The Validation Studies Manufacturing Team produces AAV at large-scale to support in vivo studies at Dyno. We are looking for a research associate to operate and assist in optimizing an adherent cell bioreactor scale production process, along with accompanying downstream purification and quality control procedures.   

How You Will Contribute

As a Sr. Research Associate - AAV Manufacturing in the Validation Studies Manufacturing Team you will help run a large-scale AAV production pipeline consisting of an upstream automated adherent cell bioreactor process, downstream purification, and quality-control assays. Your primary responsibility will be operating the pipeline to produce high-quality capsid for subsequent in vivo studies; you will also work with other members of the Validation Studies Manufacturing Team to implement process improvements, and train others on new and existing methods. Your efforts will ensure that Dyno has high-quality AAV capsids in sufficient amounts to support in vivo validation studies.        

Responsibilities: 

• Perform established AAV production, purification, and quality control protocols to attain consistent and reliable results
• Maintain cultured cell lines to support large-scale AAV production
• Communicate process improvement ideas and help integrate into pipeline when appropriate
• Train others on new and established procedures
• Create and maintain proper documentation for protocols and results 

Who you are

• Thoughtful & detail oriented
• Trusted partner
• Team oriented
• Work with a sense of urgency
• Appreciation for opportunities at the intersections of data science and biology

Basic qualifications

• BS/BA in biology, biochemistry, chemical engineering, or related fields
• 3+ years full-time hands-on laboratory experience
• Highly skilled in mammalian cell culture (aseptic technique, maintenance, transfection)
• Experience in viral vector (preferably AAV) production and purification 
• Strong communication skills
• Ability to conduct advanced procedures precisely and reproducibly
• Ability to document, maintain and present an organized account of lab work and results 

Preferred qualifications

• Experience using and maintaining bioreactors for AAV production
• 1+ years of industry experience
• Skilled in QC methods to assess AAV titer and purity including qPCR, ddPCR, Western blot, SDS-PAGE
• Skilled at ELN/LIMS usage (eg. Benchling) 

 

We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.

Job Type: Full-time