Senior/Executive Medical Director, Clinical Development (New Indications)

<div class="content-intro"><p>Alumis Inc. is a precision medicines company with the mission to transform the lives of patients with autoimmune diseases. Even with treatment innovations of the last two decades, many patients with immunologic conditions continue to suffer - our goal is to fundamentally change the outcomes for these patients.&nbsp;</p></div><p></p> <p>Alumis is advancing a proprietary portfolio of TYK2 inhibitors designed to deliver best-in-class efficacy and safety across multiple autoimmune conditions. Our lead compound, envudeucitinib (ESK-001), has demonstrated compelling clinical results in psoriasis and is advancing through pivotal studies in systemic lupus erythematosus (SLE). We are expanding our pipeline with A-005 and exploring additional indications to maximize the therapeutic potential of our portfolio.</p> <p>---</p> <p>Position Summary</p> <p>Alumis is seeking an experienced Executive Medical Director or Senior Medical Director to lead clinical development strategy and execution for Phase 1 and Phase 2 studies in neurology and additional new indications. A centerpiece of this role is A-005, Alumis’s CNS-penetrant TYK2 inhibitor with potential in neuroinflammatory and neurodegenerative diseases — a first-mover opportunity to bring a differentiated mechanism to patients with devastating neurological conditions. This high-impact role will shape Alumis’s expanding clinical portfolio from the ground up, from indication selection and study design through proof-of-concept readout, and will serve as a key scientific leader and external face of the program with investigators, regulatory authorities, and the broader medical community.</p> <p>---</p> <p>Key Responsibilities</p> <p>Clinical Development Strategy &amp; Leadership</p> <p>· Lead the design, planning, and execution of Phase 1 and Phase 2 clinical studies for A-005 in neurology (e.g., neurodegenerative diseases, movement disorders) and for additional pipeline molecules in inflammatory and immunologic indications</p> <p>· Develop and refine clinical development plans, including study synopses, protocols, and integrated development strategies for new indications</p> <p>· Provide clinical and scientific leadership to cross-functional study teams, ensuring alignment on program goals, timelines, and deliverables</p> <p>· Collaborate with Translational Medicine and Research teams to evaluate and prioritize new indication opportunities based on scientific rationale, competitive landscape, and unmet medical need</p> <p>Study Execution &amp; Oversight</p> <p>· Serve as the Medical Monitor for assigned Phase 1 and 2 studies, ensuring patient safety and scientific integrity</p> <p>· Oversee medical aspects of study conduct, including safety surveillance, protocol a