Principal Scientist, Analytical Science and Technology (ASAT), Cell Therapy

Working with Us
Challenging. Meaningful. Life-changing. Those aren’t words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You’ll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams. Take your career farther than you thought possible.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: careers.bms.com/working-with-us.

Position Summary

The Principal Scientist is a highly experienced subject matter expert responsible for leading method optimization, transfer, and validation in support of Cell Therapy analytical portfolio.  Conceptualize and lead complex projects, provides strategic scientific and technical input to the programs and projects.   Apply technical knowledge, regulatory requirements, and scientific principles to independently perform complex troubleshooting and problem solving.  The Principal Scientist balances deep hands-on laboratory involvement with cross-functional leadership, mentoring, and external scientific engagement.

Duties/Responsibilities

• Subject matter expert in Cell Biology and/or Molecular Biology, leads method technical investigation, method optimization/remediations, method transfer and method validation in compliance with regulatory requirements.

• Independently develop, write, and execute methods, protocols, reports, and other related documents aligned with regulatory and corporate guidelines.

• Conceptualize and independently lead complex projects, investigations, corrective actions and continuous improvement efforts. This includes the design and hands-on executions of laboratory experiments, evaluation of experimental data, identification of risks and impact.

• Represent the department in product review boards, regulatory inspections (internal and external audits). Own and author relevant analytical sections of regulatory submission and responses to health authority questions and requests.

• Implement method lifecycle and method maintenance programs to support methods in support of viral vector and cell therapy drug products.

• Partner with development organizations in the design of development and qualification studies, selection and characterization of reagents, and method optimization initiatives.

• Represent ASAT interest on cross functional/ cross-site teams and communicate and collaborate effectively.

• Apply technical knowledge, regulatory requirements, and scientific principles to perform troubleshooting and problem solving for non-routine complex issues.

• Perform other tasks as assigned.

Reporting Relationship

• This position will report to Analytical Science and Technology management

Qualifications

Specific Knowledge, Skills, Abilities:

• Demonstrated advanced technical writing skills.

• Advanced strategic thinking and problem-solving ability/mentality, technically adept and logical.

• Ability to work independently in a fast-paced matrix environment, meet deadlines, and prioritize work from multiple projects. Track record of scientific productivity as evidenced by publications, presentations, or equivalent internal contributions.

• Advanced ability to communicate and collaborate effectively with peers, senior management and cross-functional peers about task status, roadblocks and needs, locally and globally.

• Strong hands-on laboratory skill set, including execution, and interpretation of complex, high-impact scientific, multi-dimensional data in support of commercial QC analytical methods.

• Advanced mentoring, coaching, influencing, negotiating and personnel interaction skills.

• Strong scientific background and expertise with various analytical methodologies including those related to lentiviral, AAV vectors and other gene delivery platforms.

• Ability to travel to support projects as needed.

Education/Experience/