Study Physician, Medical Director – Neuroimmunology, Immunology, BioPharmaceuticals R&D

Introduction to role

Are you ready to lead study-level clinical decisions that accelerate transformative cell therapies and immunotherapies for patients with immune-mediated neurological disease? Join a team where bold, science-driven choices are guided by patient outcomes, and where your medical judgment directly shapes how quickly innovative treatments reach people who need them.

Brief Job Profile Description 

The Study Physician, Neuroimmunology is an expert clinical-development role within our Neuroimmunology therapeutic area. Working as the study-level clinical authority within a program led by the Global Clinical Program Lead (GCPL), you will provide expert medical and scientific input across our neuroimmunology programs. You will begin in multiple sclerosis and may contribute to additional indications, modalities, and clinical development programs as the portfolio evolves. You will partner closely with the Clinical Scientists on the study team and collaborate cross-functionally at the enterprise level, including with Oncology, Alexion, and development partners. The successful candidate will thrive in a fast-paced, proactive culture and be a strong communicator and collaborator, both internally and externally. 

You will report to the Global Clinical Head, Neuroimmunology, or their designee, and work in close partnership with the Global Clinical Program Lead, who leads the program's clinical development strategy. 

Typical Accountabilities 

• Provide expert medical and scientific input to cell-therapy and immunotherapy clinical-stage assets in development for multiple sclerosis and additional immune-mediated diseases. 

• Act as clinical authority representative for the study team. With senior support as needed, you will be responsible for the design, delivery, and interpretation of clinical studies from Phase 1 through pivotal, ensuring compliance with GCP. 

• Lead the medical assessment of causality, severity and benefit-risk for safety events, and provide medical sign-off on safety-related decisions such as dose holds and stopping-rule application. Own ongoing review and monitoring of clinical data for quality, data integrity, data-trend investigation, and safety, including SAEs, SUSARs, protocol deviations, and periodic review of emerging safety, efficacy, PK, and biomarker data both internally and via SRC/DMCs. 

• Represent the study at the Safety Review Committee, IDMC/DMC, and internal safety governance. Adjudicate complex clinical cases, including MS relapse adjudication, and sign off endpoint definitions and thresholds. 

• Support the clinical development strategy from early target identification through late phase, with senior support as necessary, and secure cross-functional alignment across the wider AZ organization. 

• Provide clinical and disease expertise to research, clinical pharmacology, translational medicine, regulatory, biostatistics, safety, the cell-therapy delivery team (including CMC), and commercial colleagues as part of a cross-functional team. 

• Follow medical developments in cell therapy and immune-mediated disease closely, and disseminate insight within Clinical Development and the wider organization to translate emerging data into innovative clinical plans. 

• Support the program at internal governance interactions and with external partners, as aligned with senior management. This includes investigators, key external experts, patient-advocacy groups, regulators, sites, and CROs.<