Associate Director, Lab Computing and Facilities Technology

Overview

Alnylam is seeking an experienced and hands-on technology leader to serve as Associate Director, Lab Computing and Facilities Technology, a role focused on delivering reliable IT infrastructure, operational support, and compliance programs for laboratory computing environments and facilities systems across Research and Early Development (ReDev), CMC, and Quality Control labs.

This role ensures laboratory environments are reliable, compliant, and fully supported for day-to-day operations across Cambridge and Norton.

This role is accountable for lab computing support across ReDev, CMC, and QC laboratories in Cambridge and Norton, lab system validation (LSV) support for QC environments in Norton, and serving as the primary IT point of contact for Facilities IT systems.

This position emphasizes tactical execution and operational excellence in supporting lab computing infrastructure, LSV, and facilities IT systems. The Associate Director will ensure lab computing environments run reliably, compliantly, and efficiently while maintaining GxP standards and data integrity across internal operations. This role requires deep technical expertise in lab computing, validation frameworks, and operational technology support.

This role is primarily based in Cambridge, MA, with regular onsite engagement (4 days per week) at our Cambridge labs and Norton QC labs to provide hands-on support and maintain close collaboration with laboratory, quality control, and facilities teams.

This role requires regular coordination across both Cambridge and Norton sites to ensure consistent, high-quality support and compliance execution.

Key Responsibilities

Deliver Reliable Lab Computing Infrastructure and Facilities IT Support

Provide operational support for lab computing environments across ReDev, CMC, and QC laboratories, including workstation management, lab-specific applications, computational resources, and network connectivity.

Serve as the primary IT point of contact for facilities IT systems including building management systems, environmental monitoring interfaces, access control systems, and equipment connectivity infrastructure, and provide IT support as needed.

Accountable for coordinating across Facilities, business owners, and enterprise IT teams to ensure Facilities and operational technology systems are supported in a fit-for-purpose manner.

Ensure high availability, performance, and reliability of lab computing and facilities IT infrastructure through proactive monitoring, incident management, and continuous improvement.

Partner with IT infrastructure, Cybersecurity and Digital Risk, and IT Data, AI & Engineering teams to ensure lab-specific requirements are met for compute, storage, data operations, networking, and security.

Define and operate a responsive lab computing support model, including service levels, escalation paths, and onsite support coverage aligned to laboratory operations needs.

Lead Lab System Validation

Oversee LSV activities for QC lab systems and instruments in Norton, with partnership support as needed across other lab environments.

Manage validation lifecycle activities including risk assessments, validation planning, protocol execution (IQ/OQ/PQ), documentation, and ongoing compliance monitoring.

Ensure lab systems meet FDA 21 CFR Part 11, EU GMP Annex 11, and data integrity requirements through robust validation frameworks and governance processes.

Support regulatory inspections and audits by maintaining audit-ready documentation, traceability matrices, and compliance records.

Partner with Quality, IT Security, and system owners to ensure validation execution is consistent, audit-ready, and aligned with enterprise standards.

Manage Instrument Integration, Connectivity, and Operational Support

Support the deployment, connectivity, and ongoing operation of laboratory instruments within the computing environment, ensuring reliable integration with enterprise and laboratory systems.

Execute instrument connectivity and endpoint integration in alignment with platform-defined standards established by the Laboratory Informatics Platforms team.

Partner with the IT laboratory informatics team to enable instrument connectivity and data flow into ELN, LIMS, and related systems.

Provide technical support for troubleshooting instrument connectivity issues, endpoint configuration challenges, and operational disruptions in lab environments.

Collaborate with vendors and system integrators to deploy and maintain instrument connectivity solutions in line with enterprise standards.

Escalate platform-level integration design and data flow requirements to the laboratory informatics platform te