Senior Scientist, Assay Development

At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at jnj.com

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Job Function:

Discovery & Pre-Clinical/Clinical Development

Job Sub Function:

Biotherapeutics R&D

Job Category:

Scientific/Technology

All Job Posting Locations:

Cambridge, Massachusetts, United States of America

Job Description:

About Innovative Medicine:

Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow.
 

Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way.
 

Learn more at https://www.jnj.com/innovative-medicine

We are searching for the best talent for a Senior Scientist, Assay Development to be onsite in Cambridge, MA.
 

Purpose:
The in Vivo Antibody Discovery group within Biologics Discovery is responsible for lead antibody generation from immunized animals with state-of-the-art technologies including single B cell sorting, hybridoma, display and microfluidics. As a member of the IVAD Group, this role will be responsible for the development and implementation of biochemical or cell-based binding and functional assays to support antibody generation against targets in different disease areas. In-depth knowledge and hands-on experience in assay development on Beacon microfluidics will be preferred. A strong understanding of cell biology and disease molecular pathways will also be important. This is a critical function in a multifaceted Biologics Discovery organization committed to bringing the next generation of biotherapeutic molecules to patients. We are looking for a motivated candidate with scientific and technical expertise who can collaborate across discovery areas to bring value to our portfolio of innovative drug concepts. Proficiency to work within a highly coordinated, fast-paced environment will be a significant attribute. An additional knowledge base in the areas of oncology, immunology, infectious disease, or cardiovascular disease would be a plus. If this sounds like you, come join our team!

You will be responsible for:

• Design and optimize biochemical/cell-based binding and functional assays with appropriate reagents for antibody screening
• Execute antibody discovery workflow on Beacon microfluidics platform to screen for functional antibody hits
• Evaluate animal serology using appropriate assays to select animals for screening
• Present research findings in internal meetings, clearly communicating scientific results and providing insights into data interpretation.
• Collaborate with multidisciplinary teams across functional areas to advance therapeutic programs in a dynamic and fast-paced environment.
• Document work accurately and promptly using Electronic Lab Notebook systems (e.g., Signal) and create detailed SOPs.

Qualifications / Requirements:

Education and Years of Experience:

• Minimum of a Bachelor’s degree is required
• PhD in Molecular Biology, Biomedical Engineering, Biochemistry or a related field is highly preferred

Required:

• Minimum 4 years of experience in the pharmaceutical industry and/or academic setting
• Hands-on experience in assay development with expertise on protein-based binding assays and cell-based binding and functional assays
• In-depth knowledge on mAb, bi-specifics and multi-specifics as ther